Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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thiItRNA sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (393 aa)    
Predicted Functional Partners:
Bccel_1013
KEGG: cysteine desulfurase; PFAM: aminotransferase class V.
 0.970
iscS
Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
  
 0.956
thiG
Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
     
 0.848
Bccel_3406
Sun protein; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. Belongs to the NusB family.
   
    0.845
Bccel_5260
PFAM: UBA/THIF-type NAD/FAD binding protein, MoeZ/MoeB domain protein; KEGG: UBA/THIF-type NAD/FAD binding protein.
    
 0.823
Bccel_1449
CoA-disulfide reductase; PFAM: Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain, pyridine nucleotide-disulfide oxidoreductase dimerization region, SirA-like domain-containing protein, Rhodanese-like protein, FAD-dependent pyridine nucleotide-disulfide oxidoreductase; KEGG: NAD(FAD)-dependent dehydrogenase; SMART: Rhodanese-like protein; Belongs to the sulfur carrier protein TusA family.
    
 0.743
mnmA
tRNA-specific 2-thiouridylase mnmA; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
  
 
 0.711
Bccel_3744
TIGRFAM: MiaB-like tRNA modifying enzyme, RNA modification enzyme, MiaB family; PFAM: Radical SAM domain protein, protein of unknown function UPF0004; KEGG: MiaB-like tRNA modifying enzyme; SMART: Elongator protein 3/MiaB/NifB.
   
  
 0.643
Bccel_0122
PFAM: UBA/THIF-type NAD/FAD binding protein; KEGG: thiF, molybdopterin/thiamine biosynthesis protein ThiF.
     
 0.642
Bccel_1713
Hypothetical protein; KEGG: glyoxalase.
    
  0.637
Your Current Organism:
Pseudobacteroides cellulosolvens
NCBI taxonomy Id: 398512
Other names: Bacteroides cellulosolvens ATCC 35603, Bacteroides cellulosolvens DSM 2933, P. cellulosolvens ATCC 35603 = DSM 2933, Pseudobacteroides cellulosolvens ATCC 35603 = DSM 2933, Pseudobacteroides cellulosolvens DSM 2933 = ATCC 35603
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