| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Bccel_1479 | Bccel_2229 | Bccel_1479 | Bccel_2229 | 6-deoxyerythronolide-B synthase; PFAM: KR domain protein, acyl carrier protein familyprotein, Beta-ketoacyl synthase, Acyl transferase; KEGG: polyketide synthase family protein; SMART: Polyketide synthase, beta-ketoacyl synthase region-containing protein, Polyketide synthase/Fatty acid synthase, KR, Polyketide synthase, acyl transferase domain-containing protein. | 6-deoxyerythronolide-B synthase, 3-oxoacyl-(acyl-carrier-protein) reductase; PFAM: Acyl transferase, Beta-ketoacyl synthase, KR domain protein, acyl carrier protein familyprotein; KEGG: polyketide synthase family protein; SMART: Polyketide synthase, beta-ketoacyl synthase region-containing protein, Polyketide synthase/Fatty acid synthase, KR, Polyketide synthase, acyl transferase domain-containing protein. | 0.999 |
| Bccel_1479 | Bccel_2291 | Bccel_1479 | Bccel_2291 | 6-deoxyerythronolide-B synthase; PFAM: KR domain protein, acyl carrier protein familyprotein, Beta-ketoacyl synthase, Acyl transferase; KEGG: polyketide synthase family protein; SMART: Polyketide synthase, beta-ketoacyl synthase region-containing protein, Polyketide synthase/Fatty acid synthase, KR, Polyketide synthase, acyl transferase domain-containing protein. | KEGG: uridine kinase; PFAM: phosphoribulokinase/uridine kinase; SMART: AAA ATPase. | 0.892 |
| Bccel_1479 | Bccel_3401 | Bccel_1479 | Bccel_3401 | 6-deoxyerythronolide-B synthase; PFAM: KR domain protein, acyl carrier protein familyprotein, Beta-ketoacyl synthase, Acyl transferase; KEGG: polyketide synthase family protein; SMART: Polyketide synthase, beta-ketoacyl synthase region-containing protein, Polyketide synthase/Fatty acid synthase, KR, Polyketide synthase, acyl transferase domain-containing protein. | TIGRFAM: ribulose-phosphate 3-epimerase; KEGG: ribulose-5-phosphate 3-epimerase; PFAM: ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. | 0.566 |
| Bccel_1479 | Bccel_3755 | Bccel_1479 | Bccel_3755 | 6-deoxyerythronolide-B synthase; PFAM: KR domain protein, acyl carrier protein familyprotein, Beta-ketoacyl synthase, Acyl transferase; KEGG: polyketide synthase family protein; SMART: Polyketide synthase, beta-ketoacyl synthase region-containing protein, Polyketide synthase/Fatty acid synthase, KR, Polyketide synthase, acyl transferase domain-containing protein. | SMART: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain-containing protein; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; KEGG: glyceraldehyde-3-phosphate dehydrogenase; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain-containing protein, Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. | 0.889 |
| Bccel_1479 | Bccel_3796 | Bccel_1479 | Bccel_3796 | 6-deoxyerythronolide-B synthase; PFAM: KR domain protein, acyl carrier protein familyprotein, Beta-ketoacyl synthase, Acyl transferase; KEGG: polyketide synthase family protein; SMART: Polyketide synthase, beta-ketoacyl synthase region-containing protein, Polyketide synthase/Fatty acid synthase, KR, Polyketide synthase, acyl transferase domain-containing protein. | TIGRFAM: ribose 5-phosphate isomerase B, sugar-phosphate isomerase, RpiB/LacA/LacB family; KEGG: RpiB/LacA/LacB family sugar-phosphate isomerase; PFAM: Ribose/galactose isomerase. | 0.624 |
| Bccel_1479 | Bccel_3797 | Bccel_1479 | Bccel_3797 | 6-deoxyerythronolide-B synthase; PFAM: KR domain protein, acyl carrier protein familyprotein, Beta-ketoacyl synthase, Acyl transferase; KEGG: polyketide synthase family protein; SMART: Polyketide synthase, beta-ketoacyl synthase region-containing protein, Polyketide synthase/Fatty acid synthase, KR, Polyketide synthase, acyl transferase domain-containing protein. | KEGG: protein tyrosine phosphatase; PFAM: Phosphotyrosine protein phosphatase I superfamily; SMART: Phosphotyrosine protein phosphatase I superfamily; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. | 0.946 |
| Bccel_1479 | Bccel_3831 | Bccel_1479 | Bccel_3831 | 6-deoxyerythronolide-B synthase; PFAM: KR domain protein, acyl carrier protein familyprotein, Beta-ketoacyl synthase, Acyl transferase; KEGG: polyketide synthase family protein; SMART: Polyketide synthase, beta-ketoacyl synthase region-containing protein, Polyketide synthase/Fatty acid synthase, KR, Polyketide synthase, acyl transferase domain-containing protein. | SMART: Pyruvate-flavodoxin oxidoreductase, EKR domain-containing protein; TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; KEGG: pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein, Pyruvate/ketoisovalerate oxidoreductase, 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein, Pyruvate-flavodoxin oxidoreductase, EKR domain-containing protein, Transketolase domain-containing protein, thiamine pyrophosphate TPP-binding domain-containing protein. | 0.905 |
| Bccel_1479 | glyA | Bccel_1479 | Bccel_1518 | 6-deoxyerythronolide-B synthase; PFAM: KR domain protein, acyl carrier protein familyprotein, Beta-ketoacyl synthase, Acyl transferase; KEGG: polyketide synthase family protein; SMART: Polyketide synthase, beta-ketoacyl synthase region-containing protein, Polyketide synthase/Fatty acid synthase, KR, Polyketide synthase, acyl transferase domain-containing protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.918 |
| Bccel_1479 | prs | Bccel_1479 | Bccel_2593 | 6-deoxyerythronolide-B synthase; PFAM: KR domain protein, acyl carrier protein familyprotein, Beta-ketoacyl synthase, Acyl transferase; KEGG: polyketide synthase family protein; SMART: Polyketide synthase, beta-ketoacyl synthase region-containing protein, Polyketide synthase/Fatty acid synthase, KR, Polyketide synthase, acyl transferase domain-containing protein. | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.907 |
| Bccel_2229 | Bccel_1479 | Bccel_2229 | Bccel_1479 | 6-deoxyerythronolide-B synthase, 3-oxoacyl-(acyl-carrier-protein) reductase; PFAM: Acyl transferase, Beta-ketoacyl synthase, KR domain protein, acyl carrier protein familyprotein; KEGG: polyketide synthase family protein; SMART: Polyketide synthase, beta-ketoacyl synthase region-containing protein, Polyketide synthase/Fatty acid synthase, KR, Polyketide synthase, acyl transferase domain-containing protein. | 6-deoxyerythronolide-B synthase; PFAM: KR domain protein, acyl carrier protein familyprotein, Beta-ketoacyl synthase, Acyl transferase; KEGG: polyketide synthase family protein; SMART: Polyketide synthase, beta-ketoacyl synthase region-containing protein, Polyketide synthase/Fatty acid synthase, KR, Polyketide synthase, acyl transferase domain-containing protein. | 0.999 |
| Bccel_2229 | Bccel_2291 | Bccel_2229 | Bccel_2291 | 6-deoxyerythronolide-B synthase, 3-oxoacyl-(acyl-carrier-protein) reductase; PFAM: Acyl transferase, Beta-ketoacyl synthase, KR domain protein, acyl carrier protein familyprotein; KEGG: polyketide synthase family protein; SMART: Polyketide synthase, beta-ketoacyl synthase region-containing protein, Polyketide synthase/Fatty acid synthase, KR, Polyketide synthase, acyl transferase domain-containing protein. | KEGG: uridine kinase; PFAM: phosphoribulokinase/uridine kinase; SMART: AAA ATPase. | 0.892 |
| Bccel_2229 | Bccel_3401 | Bccel_2229 | Bccel_3401 | 6-deoxyerythronolide-B synthase, 3-oxoacyl-(acyl-carrier-protein) reductase; PFAM: Acyl transferase, Beta-ketoacyl synthase, KR domain protein, acyl carrier protein familyprotein; KEGG: polyketide synthase family protein; SMART: Polyketide synthase, beta-ketoacyl synthase region-containing protein, Polyketide synthase/Fatty acid synthase, KR, Polyketide synthase, acyl transferase domain-containing protein. | TIGRFAM: ribulose-phosphate 3-epimerase; KEGG: ribulose-5-phosphate 3-epimerase; PFAM: ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. | 0.566 |
| Bccel_2229 | Bccel_3755 | Bccel_2229 | Bccel_3755 | 6-deoxyerythronolide-B synthase, 3-oxoacyl-(acyl-carrier-protein) reductase; PFAM: Acyl transferase, Beta-ketoacyl synthase, KR domain protein, acyl carrier protein familyprotein; KEGG: polyketide synthase family protein; SMART: Polyketide synthase, beta-ketoacyl synthase region-containing protein, Polyketide synthase/Fatty acid synthase, KR, Polyketide synthase, acyl transferase domain-containing protein. | SMART: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain-containing protein; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; KEGG: glyceraldehyde-3-phosphate dehydrogenase; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain-containing protein, Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. | 0.889 |
| Bccel_2229 | Bccel_3796 | Bccel_2229 | Bccel_3796 | 6-deoxyerythronolide-B synthase, 3-oxoacyl-(acyl-carrier-protein) reductase; PFAM: Acyl transferase, Beta-ketoacyl synthase, KR domain protein, acyl carrier protein familyprotein; KEGG: polyketide synthase family protein; SMART: Polyketide synthase, beta-ketoacyl synthase region-containing protein, Polyketide synthase/Fatty acid synthase, KR, Polyketide synthase, acyl transferase domain-containing protein. | TIGRFAM: ribose 5-phosphate isomerase B, sugar-phosphate isomerase, RpiB/LacA/LacB family; KEGG: RpiB/LacA/LacB family sugar-phosphate isomerase; PFAM: Ribose/galactose isomerase. | 0.624 |
| Bccel_2229 | Bccel_3797 | Bccel_2229 | Bccel_3797 | 6-deoxyerythronolide-B synthase, 3-oxoacyl-(acyl-carrier-protein) reductase; PFAM: Acyl transferase, Beta-ketoacyl synthase, KR domain protein, acyl carrier protein familyprotein; KEGG: polyketide synthase family protein; SMART: Polyketide synthase, beta-ketoacyl synthase region-containing protein, Polyketide synthase/Fatty acid synthase, KR, Polyketide synthase, acyl transferase domain-containing protein. | KEGG: protein tyrosine phosphatase; PFAM: Phosphotyrosine protein phosphatase I superfamily; SMART: Phosphotyrosine protein phosphatase I superfamily; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. | 0.946 |
| Bccel_2229 | Bccel_3831 | Bccel_2229 | Bccel_3831 | 6-deoxyerythronolide-B synthase, 3-oxoacyl-(acyl-carrier-protein) reductase; PFAM: Acyl transferase, Beta-ketoacyl synthase, KR domain protein, acyl carrier protein familyprotein; KEGG: polyketide synthase family protein; SMART: Polyketide synthase, beta-ketoacyl synthase region-containing protein, Polyketide synthase/Fatty acid synthase, KR, Polyketide synthase, acyl transferase domain-containing protein. | SMART: Pyruvate-flavodoxin oxidoreductase, EKR domain-containing protein; TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; KEGG: pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein, Pyruvate/ketoisovalerate oxidoreductase, 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein, Pyruvate-flavodoxin oxidoreductase, EKR domain-containing protein, Transketolase domain-containing protein, thiamine pyrophosphate TPP-binding domain-containing protein. | 0.905 |
| Bccel_2229 | glyA | Bccel_2229 | Bccel_1518 | 6-deoxyerythronolide-B synthase, 3-oxoacyl-(acyl-carrier-protein) reductase; PFAM: Acyl transferase, Beta-ketoacyl synthase, KR domain protein, acyl carrier protein familyprotein; KEGG: polyketide synthase family protein; SMART: Polyketide synthase, beta-ketoacyl synthase region-containing protein, Polyketide synthase/Fatty acid synthase, KR, Polyketide synthase, acyl transferase domain-containing protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.918 |
| Bccel_2229 | prs | Bccel_2229 | Bccel_2593 | 6-deoxyerythronolide-B synthase, 3-oxoacyl-(acyl-carrier-protein) reductase; PFAM: Acyl transferase, Beta-ketoacyl synthase, KR domain protein, acyl carrier protein familyprotein; KEGG: polyketide synthase family protein; SMART: Polyketide synthase, beta-ketoacyl synthase region-containing protein, Polyketide synthase/Fatty acid synthase, KR, Polyketide synthase, acyl transferase domain-containing protein. | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.907 |
| Bccel_2291 | Bccel_1479 | Bccel_2291 | Bccel_1479 | KEGG: uridine kinase; PFAM: phosphoribulokinase/uridine kinase; SMART: AAA ATPase. | 6-deoxyerythronolide-B synthase; PFAM: KR domain protein, acyl carrier protein familyprotein, Beta-ketoacyl synthase, Acyl transferase; KEGG: polyketide synthase family protein; SMART: Polyketide synthase, beta-ketoacyl synthase region-containing protein, Polyketide synthase/Fatty acid synthase, KR, Polyketide synthase, acyl transferase domain-containing protein. | 0.892 |
| Bccel_2291 | Bccel_2229 | Bccel_2291 | Bccel_2229 | KEGG: uridine kinase; PFAM: phosphoribulokinase/uridine kinase; SMART: AAA ATPase. | 6-deoxyerythronolide-B synthase, 3-oxoacyl-(acyl-carrier-protein) reductase; PFAM: Acyl transferase, Beta-ketoacyl synthase, KR domain protein, acyl carrier protein familyprotein; KEGG: polyketide synthase family protein; SMART: Polyketide synthase, beta-ketoacyl synthase region-containing protein, Polyketide synthase/Fatty acid synthase, KR, Polyketide synthase, acyl transferase domain-containing protein. | 0.892 |