| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Bccel_2748 | Bccel_4037 | Bccel_2748 | Bccel_4037 | KEGG: prephenate dehydrogenase; PFAM: Prephenate dehydrogenase, amino acid-binding ACT domain-containing protein. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | 0.419 |
| Bccel_2748 | hisB | Bccel_2748 | Bccel_4034 | KEGG: prephenate dehydrogenase; PFAM: Prephenate dehydrogenase, amino acid-binding ACT domain-containing protein. | HAMAP : Imidazoleglycerol-phosphate dehydratase; KEGG: imidazoleglycerol-phosphate dehydratase; PFAM: imidazoleglycerol-phosphate dehydratase. | 0.547 |
| Bccel_2748 | hisC | Bccel_2748 | Bccel_4035 | KEGG: prephenate dehydrogenase; PFAM: Prephenate dehydrogenase, amino acid-binding ACT domain-containing protein. | PFAM: aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; HAMAP : Histidinol-phosphate aminotransferase; KEGG: histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.963 |
| Bccel_4037 | Bccel_2748 | Bccel_4037 | Bccel_2748 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | KEGG: prephenate dehydrogenase; PFAM: Prephenate dehydrogenase, amino acid-binding ACT domain-containing protein. | 0.419 |
| Bccel_4037 | Bccel_4038 | Bccel_4037 | Bccel_4038 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Hypothetical protein; KEGG: ATP phosphoribosyltransferase catalytic subunit. | 0.762 |
| Bccel_4037 | hisA | Bccel_4037 | Bccel_4031 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | PFAM: histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; HAMAP : 1-(5-phosphoribosyl)-5-(5- phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase; KEGG: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.989 |
| Bccel_4037 | hisB | Bccel_4037 | Bccel_4034 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | HAMAP : Imidazoleglycerol-phosphate dehydratase; KEGG: imidazoleglycerol-phosphate dehydratase; PFAM: imidazoleglycerol-phosphate dehydratase. | 0.984 |
| Bccel_4037 | hisC | Bccel_4037 | Bccel_4035 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | PFAM: aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; HAMAP : Histidinol-phosphate aminotransferase; KEGG: histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.970 |
| Bccel_4037 | hisD | Bccel_4037 | Bccel_4036 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
| Bccel_4037 | hisF | Bccel_4037 | Bccel_4030 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.991 |
| Bccel_4037 | hisH | Bccel_4037 | Bccel_4032 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.978 |
| Bccel_4037 | hisI | Bccel_4037 | Bccel_4029 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | PFAM: phosphoribosyl-AMP cyclohydrolase, Phosphoribosyl-ATP pyrophosphohydrolase-like protein; TIGRFAM: phosphoribosyl-ATP diphosphatase; HAMAP : Phosphoribosyl-ATP pyrophosphatase, Phosphoribosyl-AMP cyclohydrolase, Histidine biosynthesis bifunctional protein hisIE; KEGG: phosphoribosyl-AMP cyclohydrolase, phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family. | 0.999 |
| Bccel_4037 | hisZ | Bccel_4037 | Bccel_4039 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.999 |
| Bccel_4038 | Bccel_4037 | Bccel_4038 | Bccel_4037 | Hypothetical protein; KEGG: ATP phosphoribosyltransferase catalytic subunit. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | 0.762 |
| Bccel_4038 | hisA | Bccel_4038 | Bccel_4031 | Hypothetical protein; KEGG: ATP phosphoribosyltransferase catalytic subunit. | PFAM: histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; HAMAP : 1-(5-phosphoribosyl)-5-(5- phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase; KEGG: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.965 |
| Bccel_4038 | hisB | Bccel_4038 | Bccel_4034 | Hypothetical protein; KEGG: ATP phosphoribosyltransferase catalytic subunit. | HAMAP : Imidazoleglycerol-phosphate dehydratase; KEGG: imidazoleglycerol-phosphate dehydratase; PFAM: imidazoleglycerol-phosphate dehydratase. | 0.948 |
| Bccel_4038 | hisC | Bccel_4038 | Bccel_4035 | Hypothetical protein; KEGG: ATP phosphoribosyltransferase catalytic subunit. | PFAM: aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; HAMAP : Histidinol-phosphate aminotransferase; KEGG: histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.948 |
| Bccel_4038 | hisD | Bccel_4038 | Bccel_4036 | Hypothetical protein; KEGG: ATP phosphoribosyltransferase catalytic subunit. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.984 |
| Bccel_4038 | hisF | Bccel_4038 | Bccel_4030 | Hypothetical protein; KEGG: ATP phosphoribosyltransferase catalytic subunit. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.967 |
| Bccel_4038 | hisH | Bccel_4038 | Bccel_4032 | Hypothetical protein; KEGG: ATP phosphoribosyltransferase catalytic subunit. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.935 |
