STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
glnE(Glutamate--ammonia-ligase) adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal tra [...] (921 aa)    
Predicted Functional Partners:
Daci_5002
TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; KEGG: aav:Aave_1442 glutamine synthetase, type I.
 
  
 0.817
glnD
UTP-GlnB uridylyltransferase, GlnD; KEGG: vei:Veis_3611 metal dependent phosphohydrolase; TIGRFAM: protein-P-II uridylyltransferase; PFAM: amino acid-binding ACT domain protein; DNA polymerase beta domain protein region; metal-dependent phosphohydrolase HD sub domain; GlnD PII-uridylyltransferase; SMART: metal-dependent phosphohydrolase HD region.
 
   
 0.811
Daci_0849
KEGG: aav:Aave_4656 hypothetical protein.
 
     0.755
Daci_0848
PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase; KEGG: aav:Aave_4655 nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase.
     
 0.648
Daci_4762
PFAM: nitrogen regulatory protein P-II; KEGG: dar:Daro_0297 nitrogen regulatory protein P-II.
 
 
 
 0.629
cmk
3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate; Belongs to the cytidylate kinase family. Type 1 subfamily.
      
 0.625
Daci_5558
PFAM: glutamine amidotransferase class-II; glutamate synthase alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: ajs:Ajs_0741 glutamate synthase (ferredoxin).
     
 0.621
Daci_4550
KEGG: ajs:Ajs_2313 ATP-dependent helicase HrpA; TIGRFAM: ATP-dependent helicase HrpA; PFAM: helicase domain protein; helicase-associated domain protein; protein of unknown function DUF1605; SMART: AAA ATPase; DEAD-like helicases.
  
     0.603
Daci_0846
Two component transcriptional regulator, LuxR family; PFAM: regulatory protein LuxR; response regulator receiver; Sigma-70 region 4 type 2; KEGG: vei:Veis_4829 response regulator receiver protein.
 
     0.569
argA
TIGRFAM: amino-acid N-acetyltransferase; PFAM: GCN5-related N-acetyltransferase; aspartate/glutamate/uridylate kinase; KEGG: ajs:Ajs_2327 amino-acid N-acetyltransferase; Belongs to the acetyltransferase family. ArgA subfamily.
 
   
 0.568
Your Current Organism:
Delftia acidovorans
NCBI taxonomy Id: 398578
Other names: D. acidovorans SPH-1, Delftia acidovorans SPH-1, Delftia acidovorans str. SPH-1, Delftia acidovorans strain SPH-1
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