Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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Score
Daci_2231Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (269 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
 0.998
Daci_2230
PFAM: protein of unknown function DUF513 hemX; KEGG: vei:Veis_1038 protein of unknown function DUF513, HemX.
 
 
 0.991
Daci_2368
TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: ajs:Ajs_2843 uroporphyrin-III C-methyltransferase.
 
 
 0.952
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
  
 
 0.951
Daci_0380
Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: aav:Aave_0327 porphobilinogen synthase; Belongs to the ALAD family.
  
 
 0.914
Daci_2229
PFAM: HemY domain protein; KEGG: aav:Aave_1996 HemY domain protein.
 
   
 0.883
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.685
Daci_5587
TIGRFAM: cytochrome c-type biogenesis protein CcsB; PFAM: cytochrome c assembly protein; KEGG: aav:Aave_0986 cytochrome c assembly protein.
  
  
 0.643
Daci_5999
PFAM: TrkA-N domain protein; TrkA-C domain protein; KEGG: aav:Aave_4544 TrkA-N domain protein.
  
    0.622
Daci_5846
KEGG: rsh:Rsph17029_1473 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase.
     
 0.616
Your Current Organism:
Delftia acidovorans
NCBI taxonomy Id: 398578
Other names: D. acidovorans SPH-1, Delftia acidovorans SPH-1, Delftia acidovorans str. SPH-1, Delftia acidovorans strain SPH-1
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