node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Spea_1162 | birA | Spea_1162 | Spea_0168 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.752 |
Spea_1162 | mltG | Spea_1162 | Spea_1922 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Aminodeoxychorismate lyase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. | 0.474 |
Spea_1162 | rlmL | Spea_1162 | Spea_1946 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Putative RNA methylase; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family. | 0.736 |
Spea_1162 | uppS | Spea_1162 | Spea_2881 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Undecaprenyl diphosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. | 0.540 |
Spea_1947 | Spea_1948 | Spea_1947 | Spea_1948 | PFAM: glutaredoxin 2; KEGG: son:SO_1852 hypothetical protein. | PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: slo:Shew_1814 ABC transporter-related protein. | 0.801 |
Spea_1947 | Spea_1949 | Spea_1947 | Spea_1949 | PFAM: glutaredoxin 2; KEGG: son:SO_1852 hypothetical protein. | KEGG: shn:Shewana3_1604 hypothetical protein. | 0.711 |
Spea_1947 | rlmL | Spea_1947 | Spea_1946 | PFAM: glutaredoxin 2; KEGG: son:SO_1852 hypothetical protein. | Putative RNA methylase; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family. | 0.807 |
Spea_1948 | Spea_1947 | Spea_1948 | Spea_1947 | PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: slo:Shew_1814 ABC transporter-related protein. | PFAM: glutaredoxin 2; KEGG: son:SO_1852 hypothetical protein. | 0.801 |
Spea_1948 | Spea_1949 | Spea_1948 | Spea_1949 | PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: slo:Shew_1814 ABC transporter-related protein. | KEGG: shn:Shewana3_1604 hypothetical protein. | 0.711 |
Spea_1948 | Spea_3915 | Spea_1948 | Spea_3915 | PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: slo:Shew_1814 ABC transporter-related protein. | TIGRFAM: small GTP-binding protein; GTP-binding protein TypA; PFAM: elongation factor G domain protein; protein synthesis factor GTP-binding; elongation factor Tu domain 2 protein; KEGG: saz:Sama_3415 virulence regulator BipA. | 0.474 |
Spea_1948 | rlmL | Spea_1948 | Spea_1946 | PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: slo:Shew_1814 ABC transporter-related protein. | Putative RNA methylase; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family. | 0.864 |
Spea_1949 | Spea_1947 | Spea_1949 | Spea_1947 | KEGG: shn:Shewana3_1604 hypothetical protein. | PFAM: glutaredoxin 2; KEGG: son:SO_1852 hypothetical protein. | 0.711 |
Spea_1949 | Spea_1948 | Spea_1949 | Spea_1948 | KEGG: shn:Shewana3_1604 hypothetical protein. | PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: slo:Shew_1814 ABC transporter-related protein. | 0.711 |
Spea_1949 | rlmL | Spea_1949 | Spea_1946 | KEGG: shn:Shewana3_1604 hypothetical protein. | Putative RNA methylase; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family. | 0.745 |
Spea_3915 | Spea_1948 | Spea_3915 | Spea_1948 | TIGRFAM: small GTP-binding protein; GTP-binding protein TypA; PFAM: elongation factor G domain protein; protein synthesis factor GTP-binding; elongation factor Tu domain 2 protein; KEGG: saz:Sama_3415 virulence regulator BipA. | PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: slo:Shew_1814 ABC transporter-related protein. | 0.474 |
Spea_3915 | pnp | Spea_3915 | Spea_3055 | TIGRFAM: small GTP-binding protein; GTP-binding protein TypA; PFAM: elongation factor G domain protein; protein synthesis factor GTP-binding; elongation factor Tu domain 2 protein; KEGG: saz:Sama_3415 virulence regulator BipA. | Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. | 0.626 |
Spea_3915 | pyrG | Spea_3915 | Spea_1184 | TIGRFAM: small GTP-binding protein; GTP-binding protein TypA; PFAM: elongation factor G domain protein; protein synthesis factor GTP-binding; elongation factor Tu domain 2 protein; KEGG: saz:Sama_3415 virulence regulator BipA. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.435 |
Spea_3915 | rlmL | Spea_3915 | Spea_1946 | TIGRFAM: small GTP-binding protein; GTP-binding protein TypA; PFAM: elongation factor G domain protein; protein synthesis factor GTP-binding; elongation factor Tu domain 2 protein; KEGG: saz:Sama_3415 virulence regulator BipA. | Putative RNA methylase; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family. | 0.699 |
birA | Spea_1162 | Spea_0168 | Spea_1162 | biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.752 |
birA | rlmL | Spea_0168 | Spea_1946 | biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Putative RNA methylase; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family. | 0.675 |