Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
rpoE2TIGRFAM: RNA polymerase sigma-70 PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; bad swissprot to RNA polymerase sigma factor sigW from Bacillus subtilis and good Ref YP hit to RpoE from Roseobacter denitrificans OCh 114; Belongs to the sigma-70 factor family. ECF subfamily. (189 aa)    
Predicted Functional Partners:
chrR1
TIGRFAM: anti-sigma factor, putative, ChrR family PFAM: Cupin 2 conserved barrel domain protein; good swissprot to Transcriptional activator chrR from Rhodobacter sphaeroides 2.4.1 and good Ref ZP hit to Anti-sigma factor ChrR from Roseovarius sp. TM1035; NCBI conserved domains: chrR; ChrR.
 
 
 0.997
Dshi_0368
PFAM: protein of unknown function DUF1365; no significant swissprot, high Ref YP hit to protein of unknown function DUF1365 from Jannaschia sp. CCS1.
 
  
 0.913
Dshi_0367
PFAM: amine oxidase; FAD dependent oxidoreductase, no significant swissprot, high ref ZP hit to Putative cyclopropane/cyclopropene fatty acid synthesis protein, flavin amine oxidase from Sulfitobacter sp. NAS-14.1.
 
  
 0.865
Dshi_0369
Putative sodium:galactoside symporter family protein; Bad swissprot hit to Uncharacterized symporter ynaJ from Bacillus subtilis and high Ref ZP hit to sodium:galactoside symporter family protein, putative from Roseobacter sp. CCS2; PF07690 MFS_1: transporter, major facilitator family.
 
  
 0.814
Dshi_0371
PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; middle swissprot hit to Uncharacterized oxidoreductase MXAN_5909 from Myxococcus xanthus DK 1622, good Ref ZP hit to Short-chain dehydrogenase/reductase family member from Loktanella vestfoldensis SKA53; NCBI conserved domains: COG4221, Short-chain alcohol dehydrogenase of unknown specificity.
 
   
 0.790
Dshi_0370
Conserved hypothetical protein; No significant swissprot, good Ref ZP hit to hypothetical protein RCCS2_10850 from Roseobacter sp. CCS2; no NCBI conserved domains.
 
    0.736
rpoB
DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.701
rpoC
DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.700
Dshi_3422
No hits to other proteins.
  
 
 0.686
rpoA
DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.665
Your Current Organism:
Dinoroseobacter shibae
NCBI taxonomy Id: 398580
Other names: D. shibae DFL 12 = DSM 16493, Dinoroseobacter shibae DFL 12, Dinoroseobacter shibae DFL 12 = DSM 16493, Dinoroseobacter shibae DSM 16493, Dinoroseobacter shibae DSM 16493 = DFL 12, Jannaschia sp. DFL-12
Server load: low (8%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.