STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Dshi_0906Binding-protein-dependent transport systems inner membrane component; ABC transporter (importer) gene cluster: membrane spanning domain (MSD); part of a heterotetramer. (244 aa)    
Predicted Functional Partners:
Dshi_0909
NMT1/THI5 like domain protein; ABC transporter (importer) gene cluster: receptor, NMT1/THI5 like domain, involved in Thiamine biosynthesis.
 
  0.999
Dshi_0907
ABC transporter (importer) gene cluster: 1st ATP binding cassette (ABC) domain; part of a heterotetramer.
 
  0.996
Dshi_0908
Transcriptional activator; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway; Belongs to the TenA family.
 
    0.922
Dshi_1173
NMT1/THI5 like domain protein; Proposed to be required for the biosynthesis of the pyrimidine moiety of thiamine.
 
    0.817
thiG
Thiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
  
    0.794
thiE
Thiamine-phosphate diphosphorylase; Magnesium dependent, Reaction: 2-Methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-Methyl-5-(2-phosphoethyl)-thiazole <=> Pyrophosphate + Thiaminmonophosphate.
  
    0.791
Dshi_0913
Thiamine biosynthesis protein ThiS; Involved in sulphur transfer.
  
    0.790
thiO
Glycine oxidase ThiO; FAD dependent oxidoreductase, active with glycine, sarcosine, N-ethylglycine, D-alanine, D-alpha-aminobutyrate, D-proline, D-pipecolate and N-methyl-D-alanine.
  
    0.790
thiD
Phosphomethylpyrimidine kinase; Cofactor biosynthesis, Reaction: ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine <=> ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine.
  
    0.790
thiF
UBA/THIF-type NAD/FAD binding protein; Contains thiF and MoeZ/B-domain.
  
    0.784
Your Current Organism:
Dinoroseobacter shibae
NCBI taxonomy Id: 398580
Other names: D. shibae DFL 12 = DSM 16493, Dinoroseobacter shibae DFL 12, Dinoroseobacter shibae DFL 12 = DSM 16493, Dinoroseobacter shibae DSM 16493, Dinoroseobacter shibae DSM 16493 = DFL 12, Jannaschia sp. DFL-12
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