Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
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[Homology]
Score
catDReaction: 3-oxoadipate enol-lactone + H2O = 3-oxoadipate. (268 aa)    
Predicted Functional Partners:
pcaC
TIGRFAM: 4-carboxymuconolactone decarboxylase PFAM: Carboxymuconolactone decarboxylase KEGG: sit:TM1040_0559 4-carboxymuconolactone decarboxylase; CMD.
 
 0.998
Dshi_2361
Hypothetical protein; COG0599: Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit Swiss-Prot: P29911-Uncharacterized 13.8 kDa protein in nqo9-nqo10 intergenic region PFAM: Carboxymuconolactone decarboxylase; related to carboxymuconolactone decarboxylase.
 
  
 0.914
Dshi_3475
PFAM: protein of unknown function DUF849 KEGG: jan:Jann_4165 protein of unknown function DUF849.
 
  
  0.913
Dshi_1323
Carboxymuconolactone decarboxylase.
    
 0.901
pcaB
TIGRFAM: 3-carboxy-cis,cis-muconate cycloisomerase PMID 15006791; (3-carboxymuconate lactonizing enzyme) (CMLE).
  
 0.894
pcaH
TIGRFAM: protocatechuate 3,4-dioxygenase, beta subunit PFAM: intradiol ring-cleavage dioxygenase KEGG: sit:TM1040_0558 protocatechuate 3,4-dioxygenase, beta subunit; (3,4-PCD).
 
   
 0.776
fabI1
Enoyl-(acyl-carrier-protein) reductase; Substrate: acyl-carrier-protein (ACP), Reaction: Acyl-ACP + NAD+ = trans-2,3-dehydroacyl-ACP + NADH.
  
  
 0.774
pcaG
KEGG: bmb:BruAb2_0580 protocatechuate 3,4-dioxygenase, alpha subunit TIGRFAM: protocatechuate 3,4-dioxygenase, alpha subunit PFAM: intradiol ring-cleavage dioxygenase; (3,4-PCD).
 
   
 0.737
pobA
P-hydroxybenzoate hydroxylase; KEGG: jan:Jann_4161 4-hydroxybenzoate 3-monooxygenase TIGRFAM: 4-hydroxybenzoate 3-monooxygenase PFAM: monooxygenase FAD-binding; PHBH; 4-hydroxybenzoate 3-monooxygenase.
 
 
 0.707
fabB
Beta-ketoacyl synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids, Substrate: acyl-carrier-protein (ACP), Reaction: Acyl-ACP + malonyl-ACP <=> 3-oxoacyl-ACP + CO2 + ACP; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
  
  
 0.703
Your Current Organism:
Dinoroseobacter shibae
NCBI taxonomy Id: 398580
Other names: D. shibae DFL 12 = DSM 16493, Dinoroseobacter shibae DFL 12, Dinoroseobacter shibae DFL 12 = DSM 16493, Dinoroseobacter shibae DSM 16493, Dinoroseobacter shibae DSM 16493 = DFL 12, Jannaschia sp. DFL-12
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