STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Dshi_1051MmgE/PrpD family protein; This family includes 2-methylcitrate dehydratase (PrpD) that is required for propionate catabolism. It catalyses the third step of the 2-methylcitric acid cycle. (449 aa)    
Predicted Functional Partners:
Dshi_1047
Conserved hypothetical protein.
 
  
 0.939
Dshi_1050
Conserved hypothetical protein.
 
    0.861
gltA1
KEGG: sit:TM1040_2728 citrate synthase.
 
  
 0.825
prpB
Methylisocitrate lyase; NCBI conserved domains: COG2513, PrpB, PEP phosphonomutase and related enzymes; PRK11320, prpB, 2-methylisocitrate lyase; middle swissprot hit to Methylisocitrate lyase from Vibrio cholerae; high Ref YP hit to isocitrate lyase family protein [Jannaschia sp. CCS1].
 
  
 0.822
Dshi_1049
Short-chain dehydrogenase/reductase SDR; Large family of oxidoreductases; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
 
    0.810
Dshi_1092
Carboxyvinyl-carboxyphosphonatephosphorylmutase; Reaction: 1-Carboxyvinyl carboxyphosphonate <=> 3-(Hydrohydroxyphosphoryl)pyruvate + CO2.
 
  
 0.805
gltA2
SWISSPROT P0ABH7: Citrate synthase; TIGR01798 citrate synthase I (hexameric type); COG: COG0372; PFAM: PF00285; PROSITE: PS00480; PRINTS: PR00143; Belongs to the citrate synthase family.
  
  
 0.788
Dshi_1048
Enoyl-CoA hydratase and 3-2trans-enoyl-CoA isomerase are two enzymes involved in fatty acid metabolism; Belongs to the enoyl-CoA hydratase/isomerase family.
  
    0.785
Dshi_2493
KEGG: pde:Pden_4111 hypothetical protein.
 
  
 0.690
Dshi_1426
Hydro-lyase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
  
  
 0.652
Your Current Organism:
Dinoroseobacter shibae
NCBI taxonomy Id: 398580
Other names: D. shibae DFL 12 = DSM 16493, Dinoroseobacter shibae DFL 12, Dinoroseobacter shibae DFL 12 = DSM 16493, Dinoroseobacter shibae DSM 16493, Dinoroseobacter shibae DSM 16493 = DFL 12, Jannaschia sp. DFL-12
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