Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Score
Dshi_2425Hypothetical protein; PFAM: Hemolysin-type calcium-binding region. (559 aa)    
Predicted Functional Partners:
Dshi_2501
ABC transporter; Swiss-Prot: P18770-Cyclolysin secretion/processing ATP-binding protein cyaB; P26760-Toxin RTX-I translocation ATP-binding protein PFAM: ABC transporter transmembrane region; ABC transporter related SMART: AAA ATPase KEGG: rde:RD1_1124 toxin secretion ABC transporter, ATP-binding component, putative; colocated with secretion protein (HylD family); associated with toxin excretion.
 
  
 0.811
Dshi_2502
Secretion protein; Swiss-Prot: Q03025-Alkaline protease secretion protein aprE TIGRFAM: type I secretion membrane fusion protein, HlyD family PFAM: secretion protein HlyD family protein KEGG: rde:RD1_1123 HlyD family secretion protein, putative; colocated with ABC transporter; HlyD family.
 
  
 0.782
Dshi_2503
Hypothetical protein.
 
   0.780
Dshi_2763
Hypothetical protein; Swiss-Prot: P09983-Hemolysin, chromosomal PFAM: Hemolysin-type calcium-binding region; related to hemolysin.
  
     0.749
hlyD
TIGRFAM: type I secretion membrane fusion protein, HlyD family PFAM: secretion protein HlyD family protein KEGG: sil:SPO3729 type I secretion membrane fusion protein, HlyD family; also middle swissprot hit to Proteases secretion protein prtE from Erwinia chrysanthemi; HlyD family.
 
  
 0.642
Dshi_3402
KEGG: rsp:RSP_0230 neutral zinc metallopeptidase CD: Zinc-dependent metalloprotease, serralysin_like subfamily.
 
     0.619
Dshi_0139
TIGRFAM: type I secretion system ATPase PFAM: ABC transporter related contains:pfam00005 pfam00664.
 
 
 0.545
Dshi_1622
SWISSPROT Q99289: Thermolabile hemolysin [Precursor]; PFAM: PF00353; PROSITE: PS00330; SPRINT: PR00313; SUPERFAMILY: SSF51120; Gene3D: G3DSA:2.150.10.10; COG: COG2931; Calcium binding.
 
  
0.538
Dshi_1397
Contains several Hemolysin-type calcium-binding repeats found in proteins that are secreted into the growth medium by a mechanism that does not require a cleaved N-terminal signal sequence.
 
  
0.536
Dshi_2280
Signal transduction histidine kinase; Differing Swiss-Prot hits: P0AEC3-Aerobic respiration control sensor protein arcB P39453-Sensor protein torS PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; Hpt domain protein.
  
 
 
 0.459
Your Current Organism:
Dinoroseobacter shibae
NCBI taxonomy Id: 398580
Other names: D. shibae DFL 12 = DSM 16493, Dinoroseobacter shibae DFL 12, Dinoroseobacter shibae DFL 12 = DSM 16493, Dinoroseobacter shibae DSM 16493, Dinoroseobacter shibae DSM 16493 = DFL 12, Jannaschia sp. DFL-12
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