node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dshi_0826 | Dshi_1426 | Dshi_0826 | Dshi_1426 | Malic protein NAD-binding; Malate decarboxylase, NAD(P) dependent(two forms of the enzyme with different kinetics), Reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH. | Hydro-lyase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | 0.986 |
Dshi_0826 | Dshi_2485 | Dshi_0826 | Dshi_2485 | Malic protein NAD-binding; Malate decarboxylase, NAD(P) dependent(two forms of the enzyme with different kinetics), Reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH. | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | 0.954 |
Dshi_0826 | Dshi_2874 | Dshi_0826 | Dshi_2874 | Malic protein NAD-binding; Malate decarboxylase, NAD(P) dependent(two forms of the enzyme with different kinetics), Reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH. | PIR: PIRSF015582 - citrate lyase, beta subunit; PFAM: PF03328; COG: COG2301 - Citrate lyase beta subunit; Gene3D: G3DSA:3.20.20.60; Belongs to the HpcH/HpaI aldolase family. | 0.852 |
Dshi_0826 | fumC | Dshi_0826 | Dshi_2334 | Malic protein NAD-binding; Malate decarboxylase, NAD(P) dependent(two forms of the enzyme with different kinetics), Reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH. | Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | 0.973 |
Dshi_0826 | glcB | Dshi_0826 | Dshi_1227 | Malic protein NAD-binding; Malate decarboxylase, NAD(P) dependent(two forms of the enzyme with different kinetics), Reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH. | Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. | 0.974 |
Dshi_0826 | gltA2 | Dshi_0826 | Dshi_1806 | Malic protein NAD-binding; Malate decarboxylase, NAD(P) dependent(two forms of the enzyme with different kinetics), Reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH. | SWISSPROT P0ABH7: Citrate synthase; TIGR01798 citrate synthase I (hexameric type); COG: COG0372; PFAM: PF00285; PROSITE: PS00480; PRINTS: PR00143; Belongs to the citrate synthase family. | 0.927 |
Dshi_0826 | maeB | Dshi_0826 | Dshi_3467 | Malic protein NAD-binding; Malate decarboxylase, NAD(P) dependent(two forms of the enzyme with different kinetics), Reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH. | NADP-dependent malic enzyme; PFAM: phosphate acetyl/butaryl transferase; malic protein domain protein; malic protein NAD-binding KEGG: sit:TM1040_2877 malate dehydrogenase (oxaloacetate decarboxylating) (NADP+)., phosphate acetyltransferase; NADP-ME. | 0.945 |
Dshi_0826 | mdh | Dshi_0826 | Dshi_2876 | Malic protein NAD-binding; Malate decarboxylase, NAD(P) dependent(two forms of the enzyme with different kinetics), Reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH. | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. | 0.968 |
Dshi_0826 | sucC2 | Dshi_0826 | Dshi_2491 | Malic protein NAD-binding; Malate decarboxylase, NAD(P) dependent(two forms of the enzyme with different kinetics), Reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH. | succinyl-CoA synthetase; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.920 |
Dshi_0826 | sucD2 | Dshi_0826 | Dshi_2492 | Malic protein NAD-binding; Malate decarboxylase, NAD(P) dependent(two forms of the enzyme with different kinetics), Reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH. | ADP-forming succinyl-CoA ligase; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.903 |
Dshi_1426 | Dshi_0826 | Dshi_1426 | Dshi_0826 | Hydro-lyase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Malic protein NAD-binding; Malate decarboxylase, NAD(P) dependent(two forms of the enzyme with different kinetics), Reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH. | 0.986 |
Dshi_1426 | Dshi_2485 | Dshi_1426 | Dshi_2485 | Hydro-lyase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | 0.612 |
Dshi_1426 | Dshi_2874 | Dshi_1426 | Dshi_2874 | Hydro-lyase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | PIR: PIRSF015582 - citrate lyase, beta subunit; PFAM: PF03328; COG: COG2301 - Citrate lyase beta subunit; Gene3D: G3DSA:3.20.20.60; Belongs to the HpcH/HpaI aldolase family. | 0.903 |
Dshi_1426 | fumC | Dshi_1426 | Dshi_2334 | Hydro-lyase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | 0.987 |
Dshi_1426 | glcB | Dshi_1426 | Dshi_1227 | Hydro-lyase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. | 0.942 |
Dshi_1426 | gltA2 | Dshi_1426 | Dshi_1806 | Hydro-lyase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | SWISSPROT P0ABH7: Citrate synthase; TIGR01798 citrate synthase I (hexameric type); COG: COG0372; PFAM: PF00285; PROSITE: PS00480; PRINTS: PR00143; Belongs to the citrate synthase family. | 0.970 |
Dshi_1426 | maeB | Dshi_1426 | Dshi_3467 | Hydro-lyase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | NADP-dependent malic enzyme; PFAM: phosphate acetyl/butaryl transferase; malic protein domain protein; malic protein NAD-binding KEGG: sit:TM1040_2877 malate dehydrogenase (oxaloacetate decarboxylating) (NADP+)., phosphate acetyltransferase; NADP-ME. | 0.987 |
Dshi_1426 | mdh | Dshi_1426 | Dshi_2876 | Hydro-lyase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. | 0.996 |
Dshi_1426 | sucC2 | Dshi_1426 | Dshi_2491 | Hydro-lyase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | succinyl-CoA synthetase; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.938 |
Dshi_1426 | sucD2 | Dshi_1426 | Dshi_2492 | Hydro-lyase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | ADP-forming succinyl-CoA ligase; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.924 |