STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sgaA1Swissprot: Q56YA5 Serine--glyoxylate aminotransferase PFAM: aminotransferase class V; aromatic amino acid beta-eliminating lyase/threonine aldolase KEGG: jan:Jann_1162 aminotransferase, class V; Serine--pyruvate aminotransferase; AGT; Alanine--glyoxylate aminotransferase. (422 aa)    
Predicted Functional Partners:
gcvP
Decarboxylating glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
  
 
 0.920
glcB
Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily.
  
 
 0.916
soxA2
SWISSPROT Q46337: Sarcosine oxidase subunit alpha; TIGRFAM: TIGR01372 sarcosine oxidase, alpha subunit family, heterotetrameric form; COG: COG0404 - Glycine cleavage system T protein (aminomethyltransferase); PFAM: PF01571, PF08669, PF07992; Belongs to the GcvT family.
  
 
 0.916
Dshi_2643
Swiss-Prot: P36234-Glycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
  
 
 0.916
gyaR
Glyoxylate reductase; COG: COG1052 - Lactate dehydrogenase and related dehydrogenases; PFAM: PF00389, PF02826; PROSITE: PS00065, PS00671; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
  
 
 0.916
Dshi_0590
PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; middle swissprot hit to Putative 2-hydroxyacid dehydrogenase ycdW from Escherichia coli K12; high Ref ZP hit to D-isomer specific 2-hydroxyacid dehydrogenase family protein from Roseovarius sp. 217.
  
 
 0.915
glyA2
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.915
glyA1
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.915
Dshi_2090
Putative serine--glyoxylate aminotransferase; COG: COG0075 - Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase; PFAM: PF00266.
  
  
 
0.914
Dshi_0888
Pyridoxal-5'-phosphate-dependent protein beta subunit; PLP dependnet enzyme, catalytic activity not clear, Swiss-Prot hits to serine racemase, threonine dehydratase.
  
 0.913
Your Current Organism:
Dinoroseobacter shibae
NCBI taxonomy Id: 398580
Other names: D. shibae DFL 12 = DSM 16493, Dinoroseobacter shibae DFL 12, Dinoroseobacter shibae DFL 12 = DSM 16493, Dinoroseobacter shibae DSM 16493, Dinoroseobacter shibae DSM 16493 = DFL 12, Jannaschia sp. DFL-12
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.