node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EAQ48579.1 | EAQ49971.1 | MED217_08530 | MED217_02435 | COG0572 Uridine kinase. | COG0213 Thymidine phosphorylase. | 0.551 |
EAQ48579.1 | EAQ50650.1 | MED217_08530 | MED217_06442 | COG0572 Uridine kinase. | 5'(3')-deoxyribonucleotidase; COG4502 Uncharacterized protein conserved in bacteria. | 0.881 |
EAQ48579.1 | gmk | MED217_08530 | MED217_00345 | COG0572 Uridine kinase. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.652 |
EAQ48579.1 | pyrE | MED217_08530 | MED217_15320 | COG0572 Uridine kinase. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.910 |
EAQ48579.1 | tdk | MED217_08530 | MED217_18676 | COG0572 Uridine kinase. | COG1435 Thymidine kinase. | 0.636 |
EAQ49234.1 | EAQ50650.1 | MED217_07511 | MED217_06442 | Putative xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 5'(3')-deoxyribonucleotidase; COG4502 Uncharacterized protein conserved in bacteria. | 0.882 |
EAQ49234.1 | dut | MED217_07511 | MED217_18140 | Putative xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.692 |
EAQ49234.1 | gmk | MED217_07511 | MED217_00345 | Putative xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.659 |
EAQ49234.1 | purH | MED217_07511 | MED217_03475 | Putative xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful). | 0.499 |
EAQ49522.1 | EAQ50650.1 | MED217_11724 | MED217_06442 | Competence-damage inducible protein; COG1058 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA; Belongs to the CinA family. | 5'(3')-deoxyribonucleotidase; COG4502 Uncharacterized protein conserved in bacteria. | 0.890 |
EAQ49971.1 | EAQ48579.1 | MED217_02435 | MED217_08530 | COG0213 Thymidine phosphorylase. | COG0572 Uridine kinase. | 0.551 |
EAQ49971.1 | EAQ50650.1 | MED217_02435 | MED217_06442 | COG0213 Thymidine phosphorylase. | 5'(3')-deoxyribonucleotidase; COG4502 Uncharacterized protein conserved in bacteria. | 0.779 |
EAQ49971.1 | pyrE | MED217_02435 | MED217_15320 | COG0213 Thymidine phosphorylase. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.518 |
EAQ49971.1 | tdk | MED217_02435 | MED217_18676 | COG0213 Thymidine phosphorylase. | COG1435 Thymidine kinase. | 0.908 |
EAQ50138.1 | EAQ50650.1 | MED217_03270 | MED217_06442 | Hypothetical protein. | 5'(3')-deoxyribonucleotidase; COG4502 Uncharacterized protein conserved in bacteria. | 0.600 |
EAQ50650.1 | EAQ48579.1 | MED217_06442 | MED217_08530 | 5'(3')-deoxyribonucleotidase; COG4502 Uncharacterized protein conserved in bacteria. | COG0572 Uridine kinase. | 0.881 |
EAQ50650.1 | EAQ49234.1 | MED217_06442 | MED217_07511 | 5'(3')-deoxyribonucleotidase; COG4502 Uncharacterized protein conserved in bacteria. | Putative xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.882 |
EAQ50650.1 | EAQ49522.1 | MED217_06442 | MED217_11724 | 5'(3')-deoxyribonucleotidase; COG4502 Uncharacterized protein conserved in bacteria. | Competence-damage inducible protein; COG1058 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA; Belongs to the CinA family. | 0.890 |
EAQ50650.1 | EAQ49971.1 | MED217_06442 | MED217_02435 | 5'(3')-deoxyribonucleotidase; COG4502 Uncharacterized protein conserved in bacteria. | COG0213 Thymidine phosphorylase. | 0.779 |
EAQ50650.1 | EAQ50138.1 | MED217_06442 | MED217_03270 | 5'(3')-deoxyribonucleotidase; COG4502 Uncharacterized protein conserved in bacteria. | Hypothetical protein. | 0.600 |