STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EAQ48747.1DNA topoisomerase IV subunit B; COG0187 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit. (618 aa)    
Predicted Functional Partners:
EAQ48746.1
COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit.
 
 0.996
gyrA
DNA gyrase A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
 
 0.989
EAQ49029.1
COG3569 Topoisomerase IB.
   
 
 0.840
argS
COG0018 Arginyl-tRNA synthetase.
  
  
 0.714
mscL
Large conductance mechanosensitive channel protein; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
     
 0.657
EAQ50731.1
MCBG protein-like (microcin resistance protein); COG1357 Uncharacterized low-complexity proteins.
   
 
 0.613
EAQ50260.1
COG3210 Large exoproteins involved in heme utilization or adhesion.
    
 
 0.611
EAQ49536.1
Hypothetical protein; COG1357 Uncharacterized low-complexity proteins.
    
 
 0.611
EAQ50954.1
COG3210 Large exoproteins involved in heme utilization or adhesion.
    
 
 0.611
dnaJ
Putative chaperone protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between Dna [...]
 
  
 0.598
Your Current Organism:
Leeuwenhoekiella blandensis
NCBI taxonomy Id: 398720
Other names: Flavobacterium sp. MED217, L. blandensis MED217, Leeuwenhoekiella blandensis MED217
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.