node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EAQ49418.1 | EAQ50249.1 | MED217_11204 | MED217_04437 | ATP-dependent Clp protease, ATP-binding subunit ClpC; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Hypothetical protein; Belongs to the ClpS family. | 0.856 |
EAQ49418.1 | clpP-2 | MED217_11204 | MED217_16175 | ATP-dependent Clp protease, ATP-binding subunit ClpC; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease proteolytic subunit 2; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.911 |
EAQ49418.1 | dnaK | MED217_11204 | MED217_10884 | ATP-dependent Clp protease, ATP-binding subunit ClpC; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.942 |
EAQ49418.1 | groL | MED217_11204 | MED217_03510 | ATP-dependent Clp protease, ATP-binding subunit ClpC; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Chaperonin, 60 kDa; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.559 |
EAQ49418.1 | grpE | MED217_11204 | MED217_14415 | ATP-dependent Clp protease, ATP-binding subunit ClpC; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | GrpE protein (Hsp-70 cofactor); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds [...] | 0.778 |
EAQ50249.1 | EAQ49418.1 | MED217_04437 | MED217_11204 | Hypothetical protein; Belongs to the ClpS family. | ATP-dependent Clp protease, ATP-binding subunit ClpC; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | 0.856 |
EAQ50249.1 | EAQ51370.1 | MED217_04437 | MED217_17545 | Hypothetical protein; Belongs to the ClpS family. | Hypothetical protein. | 0.856 |
EAQ50249.1 | clpB | MED217_04437 | MED217_12429 | Hypothetical protein; Belongs to the ClpS family. | Putative heat shock ClpB protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.856 |
EAQ50249.1 | clpP-2 | MED217_04437 | MED217_16175 | Hypothetical protein; Belongs to the ClpS family. | ATP-dependent Clp protease proteolytic subunit 2; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.661 |
EAQ50249.1 | dnaK | MED217_04437 | MED217_10884 | Hypothetical protein; Belongs to the ClpS family. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.402 |
EAQ51097.1 | clpP-2 | MED217_16180 | MED217_16175 | COG0544 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor). | ATP-dependent Clp protease proteolytic subunit 2; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.649 |
EAQ51097.1 | clpX | MED217_16180 | MED217_16170 | COG0544 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor). | ATP-dependent protease ATP-binding subunit; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.622 |
EAQ51097.1 | def | MED217_16180 | MED217_11409 | COG0544 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor). | Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. | 0.851 |
EAQ51370.1 | EAQ50249.1 | MED217_17545 | MED217_04437 | Hypothetical protein. | Hypothetical protein; Belongs to the ClpS family. | 0.856 |
EAQ51370.1 | clpP-2 | MED217_17545 | MED217_16175 | Hypothetical protein. | ATP-dependent Clp protease proteolytic subunit 2; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.880 |
EAQ51370.1 | dnaK | MED217_17545 | MED217_10884 | Hypothetical protein. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.942 |
EAQ51370.1 | groL | MED217_17545 | MED217_03510 | Hypothetical protein. | Chaperonin, 60 kDa; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.559 |
EAQ51370.1 | grpE | MED217_17545 | MED217_14415 | Hypothetical protein. | GrpE protein (Hsp-70 cofactor); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds [...] | 0.728 |
clpB | EAQ50249.1 | MED217_12429 | MED217_04437 | Putative heat shock ClpB protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Hypothetical protein; Belongs to the ClpS family. | 0.856 |
clpB | clpP-2 | MED217_12429 | MED217_16175 | Putative heat shock ClpB protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease proteolytic subunit 2; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.901 |