node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Glov_0786 | Glov_1114 | Glov_0786 | Glov_1114 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: pne:Pnec_0337 thiamine pyrophosphate protein TPP binding domain protein; Belongs to the TPP enzyme family. | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: mka:MK0531 acetolactate synthase large subunit; Belongs to the TPP enzyme family. | 0.926 |
Glov_0786 | Glov_2502 | Glov_0786 | Glov_2502 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: pne:Pnec_0337 thiamine pyrophosphate protein TPP binding domain protein; Belongs to the TPP enzyme family. | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: gur:Gura_3719 acetolactate synthase, small subunit. | 0.997 |
Glov_0786 | Glov_2503 | Glov_0786 | Glov_2503 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: pne:Pnec_0337 thiamine pyrophosphate protein TPP binding domain protein; Belongs to the TPP enzyme family. | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: gur:Gura_3720 acetolactate synthase, large subunit, biosynthetic type. | 0.922 |
Glov_0786 | Glov_3016 | Glov_0786 | Glov_3016 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: pne:Pnec_0337 thiamine pyrophosphate protein TPP binding domain protein; Belongs to the TPP enzyme family. | PFAM: glutamine amidotransferase class-II; glutamate synthase alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: amr:AM1_6366 ferredoxin dependent glutamate synthase 1, putative. | 0.614 |
Glov_0786 | Glov_3165 | Glov_0786 | Glov_3165 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: pne:Pnec_0337 thiamine pyrophosphate protein TPP binding domain protein; Belongs to the TPP enzyme family. | Homoaconitate hydratase family protein; KEGG: gme:Gmet_1268 cis-homoaconitase:3-isopropylmalate dehydratase; TIGRFAM: homoaconitate hydratase family protein; 3-isopropylmalate dehydratase; PFAM: aconitate hydratase domain protein; Belongs to the aconitase/IPM isomerase family. | 0.743 |
Glov_0786 | Glov_3166 | Glov_0786 | Glov_3166 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: pne:Pnec_0337 thiamine pyrophosphate protein TPP binding domain protein; Belongs to the TPP enzyme family. | PFAM: aconitate hydratase domain protein; KEGG: gsu:GSU1902 3-isopropylmalate dehydratase, small subunit, putative; Belongs to the LeuD family. | 0.778 |
Glov_0786 | ilvC | Glov_0786 | Glov_2501 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: pne:Pnec_0337 thiamine pyrophosphate protein TPP binding domain protein; Belongs to the TPP enzyme family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.988 |
Glov_0786 | ilvD | Glov_0786 | Glov_2505 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: pne:Pnec_0337 thiamine pyrophosphate protein TPP binding domain protein; Belongs to the TPP enzyme family. | KEGG: ppd:Ppro_2559 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.915 |
Glov_0786 | leuA | Glov_0786 | Glov_3325 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: pne:Pnec_0337 thiamine pyrophosphate protein TPP binding domain protein; Belongs to the TPP enzyme family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.916 |
Glov_0786 | leuB | Glov_0786 | Glov_0348 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: pne:Pnec_0337 thiamine pyrophosphate protein TPP binding domain protein; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.965 |
Glov_1114 | Glov_0786 | Glov_1114 | Glov_0786 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: mka:MK0531 acetolactate synthase large subunit; Belongs to the TPP enzyme family. | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: pne:Pnec_0337 thiamine pyrophosphate protein TPP binding domain protein; Belongs to the TPP enzyme family. | 0.926 |
Glov_1114 | Glov_2502 | Glov_1114 | Glov_2502 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: mka:MK0531 acetolactate synthase large subunit; Belongs to the TPP enzyme family. | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: gur:Gura_3719 acetolactate synthase, small subunit. | 0.998 |
Glov_1114 | Glov_2503 | Glov_1114 | Glov_2503 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: mka:MK0531 acetolactate synthase large subunit; Belongs to the TPP enzyme family. | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: gur:Gura_3720 acetolactate synthase, large subunit, biosynthetic type. | 0.918 |
Glov_1114 | Glov_3016 | Glov_1114 | Glov_3016 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: mka:MK0531 acetolactate synthase large subunit; Belongs to the TPP enzyme family. | PFAM: glutamine amidotransferase class-II; glutamate synthase alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: amr:AM1_6366 ferredoxin dependent glutamate synthase 1, putative. | 0.614 |
Glov_1114 | Glov_3165 | Glov_1114 | Glov_3165 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: mka:MK0531 acetolactate synthase large subunit; Belongs to the TPP enzyme family. | Homoaconitate hydratase family protein; KEGG: gme:Gmet_1268 cis-homoaconitase:3-isopropylmalate dehydratase; TIGRFAM: homoaconitate hydratase family protein; 3-isopropylmalate dehydratase; PFAM: aconitate hydratase domain protein; Belongs to the aconitase/IPM isomerase family. | 0.833 |
Glov_1114 | Glov_3166 | Glov_1114 | Glov_3166 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: mka:MK0531 acetolactate synthase large subunit; Belongs to the TPP enzyme family. | PFAM: aconitate hydratase domain protein; KEGG: gsu:GSU1902 3-isopropylmalate dehydratase, small subunit, putative; Belongs to the LeuD family. | 0.846 |
Glov_1114 | ilvC | Glov_1114 | Glov_2501 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: mka:MK0531 acetolactate synthase large subunit; Belongs to the TPP enzyme family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.990 |
Glov_1114 | ilvD | Glov_1114 | Glov_2505 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: mka:MK0531 acetolactate synthase large subunit; Belongs to the TPP enzyme family. | KEGG: ppd:Ppro_2559 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.926 |
Glov_1114 | leuA | Glov_1114 | Glov_3325 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: mka:MK0531 acetolactate synthase large subunit; Belongs to the TPP enzyme family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.941 |
Glov_1114 | leuB | Glov_1114 | Glov_0348 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: mka:MK0531 acetolactate synthase large subunit; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.977 |