STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
SHOC1Protein SHORTAGE IN CHIASMATA 1 homolog; Essential for normal crossover (CO) formation during meiosis. Essential component for the formation of class I meiotic COs. Interacts with PTD, another meiotic component, to regulate CO formation, possibly by stabilizing the recombination intermediates during meiosis. SHOC1 and PTD may form transient heterotrimeric or heterotetrametric complexes with HEI10 and/or ZIP4 to promote class I COs formation. Does not seem to be involved in early meiotic recombination steps involving double-strand break (DSB) formation, processing, and single-strand inv [...] (1709 aa)    
Predicted Functional Partners:
NIA1
Nitrate reductase [NADH] 1; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.
  
 
 0.840
Q6ZC33_ORYSJ
Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.
  
 
 0.840
Q6ZHH7_ORYSJ
Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.
  
 
 0.840
HEI10
E3 ubiquitin-protein ligase CCNB1IP1 homolog; Ubiquitin E3 ligase required for class I crossover (CO) formation during meiosis.
      
 0.760
MSH5
DNA mismatch repair protein MSH5; Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis. Promotes homologous recombination through facilitating chiasma formation during prophase I. Involved in the control of class I crossover (interference-sensitive crossover) formation. Belongs to the DNA mismatch repair MutS family.
   
 
 0.752
Q0E3L4_ORYSJ
Os02g0168100 protein.
     
 0.690
PTD
Protein PARTING DANCERS homolog; Essential for normal crossover (CO) formation during meiosis. Essential component for the formation of class I meiotic COs. Interacts with SHOC1, another meiotic component, to regulate CO formation, possibly by stabilizing the recombination intermediates during meiosis. PTD and SHOC1 may form transient heterotrimeric or heterotetrametric complexes with HEI10 and/or ZIP4 to promote class I COs formation. Does not seem to be involved in early meiotic recombination steps involving double-strand break (DSB) formation, processing, and single-strand invasion. [...]
    
 
 0.665
Q7XXS0_ORYSJ
ATP synthase subunit d, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...]
     
 0.648
MER3
ATP-dependent DNA helicase MER3 homolog; DNA helicase required for crossover formation, complete synapsis of homologous chromosomes and bivalent formation during meiosis. Is specific to recombination events resulting in interference- sensitive crossovers (class I meiotic crossover). Works cooperatively with ZIP4 to promote crossovers ; Belongs to the helicase family. SKI2 subfamily.
      
 0.642
ALDH5F1
Succinate-semialdehyde dehydrogenase, mitochondrial; Oxidizes specifically succinate semialdehyde. Involved in plant response to environmental stress by preventing the accumulation of reactive oxygen species (By similarity).
   
 0.631
Your Current Organism:
Oryza sativa Japonica
NCBI taxonomy Id: 39947
Other names: Japanese rice, Japonica rice, O. sativa Japonica Group, Oryza sativa (japonica cultivar-group), Oryza sativa Japonica Group, Oryza sativa subsp. japonica
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