STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDKB1-1Cyclin-dependent kinase B1-1. (303 aa)    
Predicted Functional Partners:
CDC6
Cell division control protein 6 homolog; May be involved in the initiation of DNA replication.
   
 0.963
CKS1
Cyclin-dependent kinases regulatory subunit 1; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function; Belongs to the CKS family.
   
 0.963
WEE1
Wee1-like protein kinase.
  
0.960
CYCB1-1
Cyclin-B1-1; Belongs to the cyclin family. Cyclin AB subfamily.
   
 0.937
CYCB1-3
Cyclin-B1-3.
   
 0.937
CYCA2-1
Cyclin-A2-1; Belongs to the cyclin family. Cyclin AB subfamily.
   
 0.932
RBR1
Retinoblastoma-related protein 1; Regulator of biological processes that recruits a histone deacetylase to control gene transcription. May play a role in the entry into mitosis, negatively regulating the cell proliferation. Formation of stable complexes with geminiviridae replication-associated proteins may create a cellular environment which favors viral DNA replication (By similarity); Belongs to the retinoblastoma protein (RB) family.
   
 0.926
ORC2
Origin of replication complex subunit 2; Essential protein (By similarity). Component of the origin recognition complex (ORC) that binds origins of replication. DNA- binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity); Belongs to the ORC2 family.
   
 0.917
CDKD-1
Cyclin-dependent kinase D-1; CDK-activating kinase that may control G1/S phase progression. May control the rate of cell differentiation to accomplish proper development of organs, or in response to a changing environment. Forms a complex with cyclin CYCH1-1 that phosphorylates CDKA-1 and the C-terminal domain (CTD) of the large subunit of RNA polymerase II.
  
0.912
CYCD7-1
Putative cyclin-D7-1; Belongs to the cyclin family. Cyclin D subfamily.
   
 0.912
Your Current Organism:
Oryza sativa Japonica
NCBI taxonomy Id: 39947
Other names: Japanese rice, Japonica rice, O. sativa Japonica Group, Oryza sativa (japonica cultivar-group), Oryza sativa Japonica Group, Oryza sativa subsp. japonica
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.