AOH38855.1 protein (Dialister pneumosintes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

AOH38855.1

Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (390 aa)

Predicted Functional Partners:

AOH38854.1

0.971

AOH39439.1

0.866

AOH38616.1

0.860

AOH38856.1

0.644

AOH39365.1

0.403

AOH38857.1

0.400

Your Current Organism:

Dialister pneumosintes

NCBI taxonomy Id: 39950
Other names: ATCC 33048, Bacillus pneumosintes, Bacterium pneumosintes, Bacteroides pneumosintes, CCUG 21025, CIP 107041, D. pneumosintes, DSM 11619, Dialister pneumosintes var. septicemiae, JCM 10004

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AOH38616.1	AOH38855.1	BCB69_00560	BCB69_02005	DNA-binding response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.860
AOH38854.1	AOH38855.1	BCB69_02000	BCB69_02005	DNA-binding response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.971
AOH38854.1	AOH38856.1	BCB69_02000	BCB69_02010	DNA-binding response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Exodeoxyribonuclease III; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.670
AOH38855.1	AOH38616.1	BCB69_02005	BCB69_00560	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	DNA-binding response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.860
AOH38855.1	AOH38854.1	BCB69_02005	BCB69_02000	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	DNA-binding response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.971
AOH38855.1	AOH38856.1	BCB69_02005	BCB69_02010	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Exodeoxyribonuclease III; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.644
AOH38855.1	AOH38857.1	BCB69_02005	BCB69_02015	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Arylsulfatase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.400
AOH38855.1	AOH39365.1	BCB69_02005	BCB69_05035	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.403
AOH38855.1	AOH39439.1	BCB69_02005	BCB69_05455	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Two-component system response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.866
AOH38856.1	AOH38854.1	BCB69_02010	BCB69_02000	Exodeoxyribonuclease III; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA-binding response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.670
AOH38856.1	AOH38855.1	BCB69_02010	BCB69_02005	Exodeoxyribonuclease III; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.644
AOH38857.1	AOH38855.1	BCB69_02015	BCB69_02005	Arylsulfatase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.400
AOH39365.1	AOH38855.1	BCB69_05035	BCB69_02005	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.403
AOH39439.1	AOH38855.1	BCB69_05455	BCB69_02005	Two-component system response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.866

Network Stats

number of nodes:

9

number of edges:

16

average node degree:

3.56

avg. local clustering coefficient:

0.713

expected number of edges:

8

PPI enrichment p-value:

0.00899

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0018106

Peptidyl-histidine phosphorylation

8 of 126

1.68

3.13

7.67e-10

GO:0007165

Signal transduction

9 of 260

1.42

2.37

7.75e-10

GO:0050794

Regulation of cellular process

10 of 590

1.11

1.48

5.37e-09

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000155

Phosphorelay sensor kinase activity

8 of 145

1.62

2.91

1.34e-09

GO:0016740

Transferase activity

9 of 1065

0.8

0.76

3.25e-05

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005886

Plasma membrane

7 of 841

0.8

0.64

0.0015

GO:0016021

Integral component of membrane

9 of 1442

0.67

0.54

0.00098

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3041

PAC motif, and Signal transduction histidine kinase-related protein, C-terminal

9 of 65

2.02

5.36

1.79e-14

CL:3044

PAC motif, and Peptidyl-histidine modification

8 of 58

2.02

5.04

2.32e-13

CL:3048

PAC motif, and Signal transduction histidine kinase-related protein, C-terminal

6 of 46

1.99

3.81

1.41e-09

CL:3396

Chemotaxis protein CheW, and Signaling receptor activity

2 of 6

2.4

1.38

0.0028

CL:3050

PAC motif, and Phytochrome chromophore attachment domain

3 of 40

1.75

1.37

0.0014

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

10 of 500

1.18

1.7

9.48e-10

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0597

Phosphoprotein

9 of 179

1.58

3.12

1.54e-11

KW-0175

Coiled coil

10 of 817

0.97

1.12

1.03e-07

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR008207

Signal transduction histidine kinase, phosphotransfer (Hpt) domain

6 of 21

2.33

4.88

8.03e-11

IPR036641

HPT domain superfamily

6 of 22

2.31

4.83

8.94e-11

IPR001789

Signal transduction response regulator, receiver domain

10 of 168

1.65

3.65

3.24e-13

IPR011006

CheY-like superfamily

10 of 170

1.65

3.62

3.24e-13

IPR004358

Signal transduction histidine kinase-related protein, C-terminal

9 of 140

1.69

3.57

5.08e-12

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00073

Histidine Phosphotransfer domain

6 of 21

2.33

5.19

1.49e-11

SM00448

cheY-homologous receiver domain

10 of 165

1.66

3.85

2.16e-14

SM00387

Histidine kinase-like ATPases

9 of 154

1.64

3.52

1.38e-12

SM00388

His Kinase A (phosphoacceptor) domain

8 of 132

1.66

3.34

3.16e-11

SM00091

PAS domain

6 of 110

1.61

2.52

8.54e-08

(more ...)

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