node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Msed_0083 | Msed_0456 | Msed_0083 | Msed_0456 | PFAM: ERCC4 domain protein. | Hypothetical protein. | 0.876 |
Msed_0083 | Msed_0669 | Msed_0083 | Msed_0669 | PFAM: ERCC4 domain protein. | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type. | 0.876 |
Msed_0083 | Msed_0839 | Msed_0083 | Msed_0839 | PFAM: ERCC4 domain protein. | PFAM: TOPRIM domain protein; DNA topoisomerase, type IA, central domain protein; SMART: DNA topoisomerase I, ATP-binding; DNA topoisomerase I, DNA-binding; Toprim sub domain protein. | 0.942 |
Msed_0083 | dbh | Msed_0083 | Msed_0598 | PFAM: ERCC4 domain protein. | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. | 0.561 |
Msed_0083 | fen | Msed_0083 | Msed_0212 | PFAM: ERCC4 domain protein. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] | 0.952 |
Msed_0083 | mre11 | Msed_0083 | Msed_0761 | PFAM: ERCC4 domain protein. | Metallophosphoesterase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.716 |
Msed_0083 | pcn-2 | Msed_0083 | Msed_1792 | PFAM: ERCC4 domain protein. | Proliferating cell nuclear antigen, PCNA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.809 |
Msed_0083 | pcn-3 | Msed_0083 | Msed_2250 | PFAM: ERCC4 domain protein. | DNA polymerase sliding clamp subunit A; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. | 0.749 |
Msed_0083 | radA | Msed_0083 | Msed_0009 | PFAM: ERCC4 domain protein. | DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. | 0.840 |
Msed_0083 | top6A | Msed_0083 | Msed_1755 | PFAM: ERCC4 domain protein. | DNA topoisomerase (ATP-hydrolyzing); Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. | 0.684 |
Msed_0456 | Msed_0083 | Msed_0456 | Msed_0083 | Hypothetical protein. | PFAM: ERCC4 domain protein. | 0.876 |
Msed_0456 | Msed_0669 | Msed_0456 | Msed_0669 | Hypothetical protein. | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type. | 0.913 |
Msed_0456 | Msed_0839 | Msed_0456 | Msed_0839 | Hypothetical protein. | PFAM: TOPRIM domain protein; DNA topoisomerase, type IA, central domain protein; SMART: DNA topoisomerase I, ATP-binding; DNA topoisomerase I, DNA-binding; Toprim sub domain protein. | 0.875 |
Msed_0456 | dbh | Msed_0456 | Msed_0598 | Hypothetical protein. | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. | 0.693 |
Msed_0456 | fen | Msed_0456 | Msed_0212 | Hypothetical protein. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] | 0.731 |
Msed_0456 | mre11 | Msed_0456 | Msed_0761 | Hypothetical protein. | Metallophosphoesterase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.866 |
Msed_0456 | pcn-2 | Msed_0456 | Msed_1792 | Hypothetical protein. | Proliferating cell nuclear antigen, PCNA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.866 |
Msed_0456 | pcn-3 | Msed_0456 | Msed_2250 | Hypothetical protein. | DNA polymerase sliding clamp subunit A; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. | 0.854 |
Msed_0456 | radA | Msed_0456 | Msed_0009 | Hypothetical protein. | DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. | 0.856 |
Msed_0669 | Msed_0083 | Msed_0669 | Msed_0083 | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type. | PFAM: ERCC4 domain protein. | 0.876 |