Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Msed_0148PFAM: biotin/lipoyl attachment domain-containing protein. (167 aa)    
Predicted Functional Partners:
Msed_0147
Biotin carboxylase; PFAM: Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein.
 
 0.999
Msed_1375
Acetyl-CoA/propionyl-CoA carboxylase; PFAM: carboxyl transferase.
 
 
 0.976
Msed_1522
TIGRFAM: 2-methylcitrate synthase/citrate synthase II; PFAM: Citrate synthase.
  
 
 0.919
Msed_0267
PFAM: AMP-dependent synthetase and ligase.
    
 0.915
Msed_1291
PFAM: AMP-dependent synthetase and ligase.
    
 0.915
Msed_1353
Acetyl-coenzyme A synthetase; TIGRFAM: acetate--CoA ligase; PFAM: AMP-dependent synthetase and ligase.
    
 0.915
Msed_0639
methylmalonyl-CoA epimerase; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase.
  
 
  0.909
Msed_0709
succinyl-CoA reductase (NADPH); Catalyzes the reduction of malonyl-CoA to malonate semialdehyde, a key step in the 3-hydroxypropanoate and the 3- hydroxypropanoate/4-hydroxybutyrate cycles. Belongs to the aspartate-semialdehyde dehydrogenase family.
    
 0.908
Msed_1399
PFAM: CoA-binding domain protein.
    
 0.904
Msed_1426
acrylyl-CoA reductase (NADPH); Plays a role in autotrophic carbon fixation via the 3- hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the acryloyl-CoA dependent NADPH oxidation and formation of propionyl-CoA. Belongs to the zinc-containing alcohol dehydrogenase family.
    
  0.902
Your Current Organism:
Metallosphaera sedula
NCBI taxonomy Id: 399549
Other names: M. sedula DSM 5348, Metallosphaera sedula DSM 5348, Metallosphaera sedula IFO 15509, Metallosphaera sedula JCM 9185, Metallosphaera sedula NBRC 15509, Metallosphaera sedula str. DSM 5348, Metallosphaera sedula strain DSM 5348
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