STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Msed_0210TIGRFAM: AAA family ATPase, CDC48 subfamily; PFAM: AAA ATPase VAT domain protein; AAA ATPase, central domain protein; cell division protein 48, CDC48, domain 2; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase. (768 aa)    
Predicted Functional Partners:
Msed_2237
TIGRFAM: AAA family ATPase, CDC48 subfamily; PFAM: AAA ATPase VAT domain protein; AAA ATPase, central domain protein; cell division protein 48, CDC48, domain 2; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase.
  
  
 
0.902
Msed_0533
PFAM: histone deacetylase superfamily.
   
 0.826
Msed_1556
PFAM: histone deacetylase superfamily.
   
 0.826
Msed_0211
Hypothetical protein.
       0.792
rpl40e
PFAM: ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family.
  
 0.762
fen
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...]
  
 
 0.749
Msed_0813
PFAM: TPR repeat-containing protein; SMART: Tetratricopeptide domain protein.
  
 0.729
Msed_1532
PFAM: TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide domain protein.
  
 0.729
Msed_0329
PFAM: protein kinase; SMART: serine/threonine protein kinase.
 
 
 0.721
psmA
Proteasome endopeptidase complex; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
  
 0.707
Your Current Organism:
Metallosphaera sedula
NCBI taxonomy Id: 399549
Other names: M. sedula DSM 5348, Metallosphaera sedula DSM 5348, Metallosphaera sedula IFO 15509, Metallosphaera sedula JCM 9185, Metallosphaera sedula NBRC 15509, Metallosphaera sedula str. DSM 5348, Metallosphaera sedula strain DSM 5348
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.