STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Msed_02792,3-dimethylmalate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. (274 aa)    
Predicted Functional Partners:
Msed_0278
2-methylcitrate dehydratase; PFAM: MmgE/PrpD family protein.
 
  
 0.996
Msed_1042
PFAM: malate synthase.
 
 0.973
Msed_1467
Aconitase; TIGRFAM: aconitate hydratase 1; PFAM: aconitate hydratase domain protein.
  
 0.958
Msed_0281
TIGRFAM: 2-methylcitrate synthase/citrate synthase II; PFAM: Citrate synthase.
  
 
 0.948
sucD
succinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 0.932
Msed_1582
succinyl-CoA synthetase (ADP-forming) beta subunit; PFAM: ATP-citrate lyase/succinyl-CoA ligase; ATP-grasp domain protein.
  
 
 0.927
Msed_0267
PFAM: AMP-dependent synthetase and ligase.
  
 
 0.903
Msed_1291
PFAM: AMP-dependent synthetase and ligase.
  
 
 0.903
Msed_1353
Acetyl-coenzyme A synthetase; TIGRFAM: acetate--CoA ligase; PFAM: AMP-dependent synthetase and ligase.
  
 
 0.903
Msed_0270
Acetyl-CoA acetyltransferase-like protein.
  
 
 0.864
Your Current Organism:
Metallosphaera sedula
NCBI taxonomy Id: 399549
Other names: M. sedula DSM 5348, Metallosphaera sedula DSM 5348, Metallosphaera sedula IFO 15509, Metallosphaera sedula JCM 9185, Metallosphaera sedula NBRC 15509, Metallosphaera sedula str. DSM 5348, Metallosphaera sedula strain DSM 5348
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