Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Msed_0880Nitrite and sulphite reductase 4Fe-4S region; PFAM: nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein; nitrite and sulphite reductase 4Fe-4S region. (445 aa)    
Predicted Functional Partners:
Msed_0882
Assimilatory nitrate reductase (ferredoxin) precursor; PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region.
 
  
 0.982
Msed_0881
PFAM: major facilitator superfamily MFS_1.
 
 
 0.981
cysH
Phosphoadenylylsulfate reductase (thioredoxin); Appears to have a role in S metabolism; TIGRFAM: adenylylsulfate reductase, thioredoxin dependent; PFAM: phosphoadenosine phosphosulfate reductase.
  
 0.958
Msed_2074
Glutamate dehydrogenase (NAD/NADP); PFAM: Glu/Leu/Phe/Val dehydrogenase, C terminal; Glu/Leu/Phe/Val dehydrogenase, dimerisation region; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
    
 0.918
Msed_0602
PFAM: glutamine synthetase, catalytic region.
    
 0.916
Msed_1612
TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase, catalytic region; glutamine synthetase, beta-Grasp.
    
 0.916
cysN
Sulfate adenylyltransferase; Appears to have a role in S metabolism; PFAM: ATP-sulfurylase.
  
  
 0.882
Msed_0608
TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family.
 
  
 0.876
cysG
Appears to have a role in S metabolism; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase.
 
  
 0.874
Msed_1781
PFAM: binding-protein-dependent transport systems inner membrane component.
  
  
 0.760
Your Current Organism:
Metallosphaera sedula
NCBI taxonomy Id: 399549
Other names: M. sedula DSM 5348, Metallosphaera sedula DSM 5348, Metallosphaera sedula IFO 15509, Metallosphaera sedula JCM 9185, Metallosphaera sedula NBRC 15509, Metallosphaera sedula str. DSM 5348, Metallosphaera sedula strain DSM 5348
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