STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hypAHydrogenase expression/synthesis, HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (142 aa)    
Predicted Functional Partners:
Msed_0914
ATPase involved in chromosome partitioning-like protein.
 
 
   0.974
ureG
Urease accessory protein UreG; Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
  
 
 0.967
Msed_0920
Coenzyme F420-reducing hydrogenase alpha subunit-like protein.
  
 
 0.910
Msed_0915
TIGRFAM: [NiFe] hydrogenase maturation protein HypF; PFAM: acylphosphatase; SUA5/yciO/yrdC, N-terminal domain; zinc finger, HypF domain protein.
 
   
 0.900
Msed_0888
TIGRFAM: urease, beta subunit; urease, gamma subunit; PFAM: Urease, beta subunit; Urease, gamma subunit region.
     
 0.884
Msed_2173
ATPase involved in chromosome partitioning-like protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family.
   
   0.841
Msed_0930
PFAM: hydrogenase formation HypD protein.
  
  
 0.835
Msed_0945
Ni Fe-hydrogenase I large subunit-like protein.
 
 
 0.828
Msed_0916
Hydrogenase 2 maturation peptidase, Aspartic peptidase, MEROPS family A31; TIGRFAM: hydrogenase maturation protease; PFAM: peptidase M52, hydrogen uptake protein.
  
  
 0.827
Msed_0923
PFAM: nickel-dependent hydrogenase, large subunit.
  
 
 0.783
Your Current Organism:
Metallosphaera sedula
NCBI taxonomy Id: 399549
Other names: M. sedula DSM 5348, Metallosphaera sedula DSM 5348, Metallosphaera sedula IFO 15509, Metallosphaera sedula JCM 9185, Metallosphaera sedula NBRC 15509, Metallosphaera sedula str. DSM 5348, Metallosphaera sedula strain DSM 5348
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