STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Msed_0923PFAM: nickel-dependent hydrogenase, large subunit. (513 aa)    
Predicted Functional Partners:
Msed_0924
PFAM: NADH ubiquinone oxidoreductase, 20 kDa subunit.
 
 0.999
Msed_0944
PFAM: Nickel-iron dehydrogenase small subunit, N-terminal domain protein.
 
 0.997
Msed_0920
Coenzyme F420-reducing hydrogenase alpha subunit-like protein.
 
  
0.936
Msed_0945
Ni Fe-hydrogenase I large subunit-like protein.
  
  
 
0.929
Msed_1545
PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase.
  
 
 0.794
hypA
Hydrogenase expression/synthesis, HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
  
 
 0.783
Msed_0921
Hypothetical protein.
       0.779
Msed_0916
Hydrogenase 2 maturation peptidase, Aspartic peptidase, MEROPS family A31; TIGRFAM: hydrogenase maturation protease; PFAM: peptidase M52, hydrogen uptake protein.
 
  
 0.777
Msed_0922
Hypothetical protein.
       0.773
Msed_0930
PFAM: hydrogenase formation HypD protein.
 
 
 0.727
Your Current Organism:
Metallosphaera sedula
NCBI taxonomy Id: 399549
Other names: M. sedula DSM 5348, Metallosphaera sedula DSM 5348, Metallosphaera sedula IFO 15509, Metallosphaera sedula JCM 9185, Metallosphaera sedula NBRC 15509, Metallosphaera sedula str. DSM 5348, Metallosphaera sedula strain DSM 5348
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.