Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Msed_0926Transcriptional regulator, HxlR family; PFAM: helix-turn-helix, HxlR type. (118 aa)    
Predicted Functional Partners:
Msed_0929
PFAM: class II aldolase/adducin family protein.
       0.701
Msed_0927
Hypothetical protein.
       0.686
Msed_0928
Hypothetical protein.
       0.686
Msed_0930
PFAM: hydrogenase formation HypD protein.
       0.686
Msed_0931
TIGRFAM: hydrogenase assembly chaperone hypC/hupF; PFAM: hydrogenase expression/formation protein (HUPF/HYPC).
       0.686
Msed_0932
Hypothetical protein.
       0.686
Msed_0933
TIGRFAM: hydrogenase expression/formation protein HypE; PFAM: AIR synthase related protein; AIR synthase related protein domain protein.
       0.686
Msed_0415
PFAM: NADH:flavin oxidoreductase/NADH oxidase.
     
 0.503
cobB
Silent information regulator protein Sir2; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription; Belongs to the sirtuin family. Class U subfamily.
  
    0.452
Msed_0265
Transcriptional regulator, HxlR family; PFAM: regulatory protein, ArsR; helix-turn-helix, HxlR type.
  
     0.445
Your Current Organism:
Metallosphaera sedula
NCBI taxonomy Id: 399549
Other names: M. sedula DSM 5348, Metallosphaera sedula DSM 5348, Metallosphaera sedula IFO 15509, Metallosphaera sedula JCM 9185, Metallosphaera sedula NBRC 15509, Metallosphaera sedula str. DSM 5348, Metallosphaera sedula strain DSM 5348
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