Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Msed_0945Ni Fe-hydrogenase I large subunit-like protein. (745 aa)    
Predicted Functional Partners:
Msed_0944
PFAM: Nickel-iron dehydrogenase small subunit, N-terminal domain protein.
 
 0.999
Msed_0924
PFAM: NADH ubiquinone oxidoreductase, 20 kDa subunit.
 
 0.996
Msed_0920
Coenzyme F420-reducing hydrogenase alpha subunit-like protein.
 
  
 0.970
Msed_0923
PFAM: nickel-dependent hydrogenase, large subunit.
  
  
 
0.929
Msed_0916
Hydrogenase 2 maturation peptidase, Aspartic peptidase, MEROPS family A31; TIGRFAM: hydrogenase maturation protease; PFAM: peptidase M52, hydrogen uptake protein.
 
  
 0.857
hypA
Hydrogenase expression/synthesis, HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
 
 0.828
Msed_0946
Hypothetical protein.
     
 0.798
Msed_1545
PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase.
  
 
 0.794
Msed_0947
Fe-S oxidoreductase-like protein.
 
 
 
 0.777
Msed_0930
PFAM: hydrogenase formation HypD protein.
 
 
 0.726
Your Current Organism:
Metallosphaera sedula
NCBI taxonomy Id: 399549
Other names: M. sedula DSM 5348, Metallosphaera sedula DSM 5348, Metallosphaera sedula IFO 15509, Metallosphaera sedula JCM 9185, Metallosphaera sedula NBRC 15509, Metallosphaera sedula str. DSM 5348, Metallosphaera sedula strain DSM 5348
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