STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
cysGAppears to have a role in S metabolism; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase. (227 aa)    
Predicted Functional Partners:
Msed_0213
TIGRFAM: siroheme synthase; PFAM: TrkA-N domain protein.
 
 
 0.988
cysI
Sulfite reductase (NADPH) beta subunit; Appears to have a role in S metabolism; PFAM: nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein; nitrite and sulphite reductase 4Fe-4S region.
 
  
 0.974
Msed_0218
Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
 
 
 0.947
Msed_0693
PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase.
 
 
 0.938
Msed_0608
TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family.
  
  
 
0.908
cysH
Phosphoadenylylsulfate reductase (thioredoxin); Appears to have a role in S metabolism; TIGRFAM: adenylylsulfate reductase, thioredoxin dependent; PFAM: phosphoadenosine phosphosulfate reductase.
 
  
 0.908
cysN
Sulfate adenylyltransferase; Appears to have a role in S metabolism; PFAM: ATP-sulfurylase.
  
  
 0.883
Msed_0880
Nitrite and sulphite reductase 4Fe-4S region; PFAM: nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein; nitrite and sulphite reductase 4Fe-4S region.
 
  
 0.874
hemC
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
  
 0.836
cbiX
Cobalamin (vitamin B12) biosynthesis CbiX protein; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Belongs to the CbiX family. CbiXS subfamily.
  
  
 0.726
Your Current Organism:
Metallosphaera sedula
NCBI taxonomy Id: 399549
Other names: M. sedula DSM 5348, Metallosphaera sedula DSM 5348, Metallosphaera sedula IFO 15509, Metallosphaera sedula JCM 9185, Metallosphaera sedula NBRC 15509, Metallosphaera sedula str. DSM 5348, Metallosphaera sedula strain DSM 5348
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