cobB protein (Metallosphaera sedula) - STRING interaction network

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cobB

Silent information regulator protein Sir2; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription; Belongs to the sirtuin family. Class U subfamily. (245 aa)

Predicted Functional Partners:

Msed_0004

0.967

nadK

0.961

nadE

0.931

Msed_0740

0.924

Msed_0533

0.849

Msed_1556

0.849

Msed_2074

0.843

Msed_0703

0.819

Msed_1365

0.785

Msed_0415

0.746

Your Current Organism:

Metallosphaera sedula

NCBI taxonomy Id: 399549
Other names: M. sedula DSM 5348, Metallosphaera sedula DSM 5348, Metallosphaera sedula IFO 15509, Metallosphaera sedula JCM 9185, Metallosphaera sedula NBRC 15509, Metallosphaera sedula str. DSM 5348, Metallosphaera sedula strain DSM 5348

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Msed_0004	Msed_0740	Msed_0004	Msed_0740	TIGRFAM: nicotinamide-nucleotide adenylyltransferase; PFAM: cytidylyltransferase.	PFAM: ATP-NAD/AcoX kinase.	0.921
Msed_0004	cobB	Msed_0004	Msed_1096	TIGRFAM: nicotinamide-nucleotide adenylyltransferase; PFAM: cytidylyltransferase.	Silent information regulator protein Sir2; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription; Belongs to the sirtuin family. Class U subfamily.	0.967
Msed_0004	nadE	Msed_0004	Msed_0716	TIGRFAM: nicotinamide-nucleotide adenylyltransferase; PFAM: cytidylyltransferase.	NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.	0.959
Msed_0004	nadK	Msed_0004	Msed_1268	TIGRFAM: nicotinamide-nucleotide adenylyltransferase; PFAM: cytidylyltransferase.	NAD(+) kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	0.931
Msed_0415	Msed_2074	Msed_0415	Msed_2074	PFAM: NADH:flavin oxidoreductase/NADH oxidase.	Glutamate dehydrogenase (NAD/NADP); PFAM: Glu/Leu/Phe/Val dehydrogenase, C terminal; Glu/Leu/Phe/Val dehydrogenase, dimerisation region; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.600
Msed_0415	cobB	Msed_0415	Msed_1096	PFAM: NADH:flavin oxidoreductase/NADH oxidase.	Silent information regulator protein Sir2; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription; Belongs to the sirtuin family. Class U subfamily.	0.746
Msed_0415	nadK	Msed_0415	Msed_1268	PFAM: NADH:flavin oxidoreductase/NADH oxidase.	NAD(+) kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	0.624
Msed_0533	Msed_1365	Msed_0533	Msed_1365	PFAM: histone deacetylase superfamily.	PFAM: tyrosine specific protein phosphatase; Dual specificity protein phosphatase; SMART: protein tyrosine phosphatase, catalytic region.	0.547
Msed_0533	cobB	Msed_0533	Msed_1096	PFAM: histone deacetylase superfamily.	Silent information regulator protein Sir2; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription; Belongs to the sirtuin family. Class U subfamily.	0.849
Msed_0703	Msed_2074	Msed_0703	Msed_2074	TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: isocitrate/isopropylmalate dehydrogenase.	Glutamate dehydrogenase (NAD/NADP); PFAM: Glu/Leu/Phe/Val dehydrogenase, C terminal; Glu/Leu/Phe/Val dehydrogenase, dimerisation region; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.954
Msed_0703	cobB	Msed_0703	Msed_1096	TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: isocitrate/isopropylmalate dehydrogenase.	Silent information regulator protein Sir2; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription; Belongs to the sirtuin family. Class U subfamily.	0.819
Msed_0740	Msed_0004	Msed_0740	Msed_0004	PFAM: ATP-NAD/AcoX kinase.	TIGRFAM: nicotinamide-nucleotide adenylyltransferase; PFAM: cytidylyltransferase.	0.921
Msed_0740	cobB	Msed_0740	Msed_1096	PFAM: ATP-NAD/AcoX kinase.	Silent information regulator protein Sir2; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription; Belongs to the sirtuin family. Class U subfamily.	0.924
Msed_0740	nadE	Msed_0740	Msed_0716	PFAM: ATP-NAD/AcoX kinase.	NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.	0.934
Msed_0740	nadK	Msed_0740	Msed_1268	PFAM: ATP-NAD/AcoX kinase.	NAD(+) kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	0.921
Msed_1365	Msed_0533	Msed_1365	Msed_0533	PFAM: tyrosine specific protein phosphatase; Dual specificity protein phosphatase; SMART: protein tyrosine phosphatase, catalytic region.	PFAM: histone deacetylase superfamily.	0.547
Msed_1365	Msed_1556	Msed_1365	Msed_1556	PFAM: tyrosine specific protein phosphatase; Dual specificity protein phosphatase; SMART: protein tyrosine phosphatase, catalytic region.	PFAM: histone deacetylase superfamily.	0.547
Msed_1365	cobB	Msed_1365	Msed_1096	PFAM: tyrosine specific protein phosphatase; Dual specificity protein phosphatase; SMART: protein tyrosine phosphatase, catalytic region.	Silent information regulator protein Sir2; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription; Belongs to the sirtuin family. Class U subfamily.	0.785
Msed_1556	Msed_1365	Msed_1556	Msed_1365	PFAM: histone deacetylase superfamily.	PFAM: tyrosine specific protein phosphatase; Dual specificity protein phosphatase; SMART: protein tyrosine phosphatase, catalytic region.	0.547
Msed_1556	cobB	Msed_1556	Msed_1096	PFAM: histone deacetylase superfamily.	Silent information regulator protein Sir2; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription; Belongs to the sirtuin family. Class U subfamily.	0.849

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