STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Msed_1220Vinylacetyl-CoA Delta-isomerase; PFAM: 4-hydroxyphenylacetate 3-hydroxylase. (459 aa)    
Predicted Functional Partners:
Msed_1422
4-hydroxybutyryl-CoA synthetase.
    
 0.966
Msed_1321
Vinylacetyl-CoA Delta-isomerase; PFAM: 4-hydroxyphenylacetate 3-hydroxylase.
  
  
 
0.914
Msed_0389
PFAM: 3-hydroxyacyl-CoA dehydrogenase domain protein; 3-hydroxyacyl-CoA dehydrogenase, NAD-binding.
    
 0.910
Msed_0399
PFAM: Enoyl-CoA hydratase/isomerase; 3-hydroxyacyl-CoA dehydrogenase domain protein; 3-hydroxyacyl-CoA dehydrogenase, NAD-binding; Belongs to the enoyl-CoA hydratase/isomerase family.
    
 0.910
Msed_1423
PFAM: 3-hydroxyacyl-CoA dehydrogenase domain protein; 3-hydroxyacyl-CoA dehydrogenase, NAD-binding.
    
 0.910
Msed_0384
PFAM: Enoyl-CoA hydratase/isomerase; Belongs to the enoyl-CoA hydratase/isomerase family.
    
 0.907
Msed_0394
AMP-dependent synthetase and ligase; Catalyzes the ligation of coenzyme A (CoA) to 4- hydroxybutyrate (4HB). It can also use butyrate, valerate, propionate, acetate and 3-hydroxybutyrate (3HB) as substrates.
    
  0.904
Msed_0406
AMP-dependent synthetase and ligase; Involved in the 3-hydroxypropionate/4-hydroxybutyrate cycle which incorporates carbon dioxide into cellular carbon. Catalyzes the ligation of coenzyme A (CoA) to 4-hydroxybutyrate (4HB). It can also use butyrate, valerate, propionate, acetate and 3-hydroxybutyrate (3HB) as substrates; Belongs to the ATP-dependent AMP-binding enzyme family.
    
  0.900
Msed_0639
methylmalonyl-CoA epimerase; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase.
     
 0.779
Msed_1375
Acetyl-CoA/propionyl-CoA carboxylase; PFAM: carboxyl transferase.
     
 0.722
Your Current Organism:
Metallosphaera sedula
NCBI taxonomy Id: 399549
Other names: M. sedula DSM 5348, Metallosphaera sedula DSM 5348, Metallosphaera sedula IFO 15509, Metallosphaera sedula JCM 9185, Metallosphaera sedula NBRC 15509, Metallosphaera sedula str. DSM 5348, Metallosphaera sedula strain DSM 5348
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