STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Msed_1223PFAM: short-chain dehydrogenase/reductase SDR. (254 aa)    
Predicted Functional Partners:
mre11
Metallophosphoesterase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family.
  
 
 0.711
Msed_1216
PFAM: MaoC domain protein dehydratase.
  
 0.655
Msed_0329
PFAM: protein kinase; SMART: serine/threonine protein kinase.
  
 0.614
Msed_0833
PFAM: protein kinase; SMART: tyrosine protein kinase; serine/threonine protein kinase.
  
 0.614
Msed_0863
PFAM: protein kinase; SMART: tyrosine protein kinase; serine/threonine protein kinase.
  
 0.614
Msed_1797
PFAM: protein kinase; SMART: serine/threonine protein kinase.
  
 0.614
Msed_0415
PFAM: NADH:flavin oxidoreductase/NADH oxidase.
 
  
 0.553
fni
Isopentenyl-diphosphate delta-isomerase, type 2; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
  
 0.550
Msed_0336
PFAM: Enoyl-CoA hydratase/isomerase.
  
 0.541
Msed_0384
PFAM: Enoyl-CoA hydratase/isomerase; Belongs to the enoyl-CoA hydratase/isomerase family.
  
 0.541
Your Current Organism:
Metallosphaera sedula
NCBI taxonomy Id: 399549
Other names: M. sedula DSM 5348, Metallosphaera sedula DSM 5348, Metallosphaera sedula IFO 15509, Metallosphaera sedula JCM 9185, Metallosphaera sedula NBRC 15509, Metallosphaera sedula str. DSM 5348, Metallosphaera sedula strain DSM 5348
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