STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Msed_1243PFAM: cobalamin B12-binding domain protein; Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. (533 aa)    
Predicted Functional Partners:
Msed_1241
TIGRFAM: mercuric reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; FAD dependent oxidoreductase; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
  
    0.534
dnaG
TOPRIM domain protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.
 
     0.531
Msed_1242
SMART: TRASH domain protein.
       0.518
Msed_0919
PFAM: Radical SAM domain protein.
 
  
 0.488
Msed_1075
PFAM: Squalene/phytoene synthase.
 
  
 0.469
Msed_1933
Geranylgeranylglycerol-phosphate geranylgeranyltransferase; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
 
  
 0.461
Msed_2089
Cobaltochelatase CobN subunit; PFAM: CobN/magnesium chelatase.
 
  
 0.456
Msed_1284
PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB.
 
   
 0.443
Msed_0681
2,3-di-O-geranylgeranylglyceryl phosphate reductase; TIGRFAM: geranylgeranyl reductase; PFAM: FAD dependent oxidoreductase.
 
  
 0.415
Msed_2096
TIGRFAM: 4-hydroxybenzoate polyprenyltransferase, putative; PFAM: UbiA prenyltransferase.
 
  
 0.404
Your Current Organism:
Metallosphaera sedula
NCBI taxonomy Id: 399549
Other names: M. sedula DSM 5348, Metallosphaera sedula DSM 5348, Metallosphaera sedula IFO 15509, Metallosphaera sedula JCM 9185, Metallosphaera sedula NBRC 15509, Metallosphaera sedula str. DSM 5348, Metallosphaera sedula strain DSM 5348
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