Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Msed_1265Mn2+ and Fe2+ transporter of the NRAMP family-like protein. (390 aa)    
Predicted Functional Partners:
Msed_0505
TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; plasma-membrane proton-efflux P-type ATPase; PFAM: cation transporting ATPase domain protein; Haloacid dehalogenase domain protein hydrolase; E1-E2 ATPase-associated domain protein.
 
 
 0.717
Msed_1263
PFAM: Rieske [2Fe-2S] domain protein.
     
 0.624
Msed_0636
PFAM: type I phosphodiesterase/nucleotide pyrophosphatase.
 
 
 0.607
Msed_0845
PFAM: type I phosphodiesterase/nucleotide pyrophosphatase.
 
 
 0.604
Msed_0409
Amino acid/polyamine/organocation transporter, APC superfamily; PFAM: amino acid permease-associated region; TC 2.A.3.
 
   
 0.570
Msed_1264
Ferritin, Dps family protein; Protects DNA from oxidative damage by sequestering intracellular Fe2+ ion and storing it in the form of Fe3+ oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe2+ ions, which prevents hydroxyl radical production by the Fenton reaction. Belongs to the Dps family.
     
 0.559
Msed_0903
TIGRFAM: cation diffusion facilitator family transporter; PFAM: cation efflux protein.
 
 
 0.547
Msed_1914
PFAM: V-type ATPase, 116 kDa subunit; Belongs to the V-ATPase 116 kDa subunit family.
   
 0.519
Msed_0851
Physarolisin II, Serine peptidase, MEROPS family S53; PFAM: peptidase S8 and S53, subtilisin, kexin, sedolisin.
 
     0.503
Msed_0490
Heavy metal translocating P-type ATPase; TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; copper-translocating P-type ATPase; heavy metal translocating P-type ATPase; PFAM: Haloacid dehalogenase domain protein hydrolase; Heavy metal transport/detoxification protein; E1-E2 ATPase-associated domain protein.
 
 
 0.496
Your Current Organism:
Metallosphaera sedula
NCBI taxonomy Id: 399549
Other names: M. sedula DSM 5348, Metallosphaera sedula DSM 5348, Metallosphaera sedula IFO 15509, Metallosphaera sedula JCM 9185, Metallosphaera sedula NBRC 15509, Metallosphaera sedula str. DSM 5348, Metallosphaera sedula strain DSM 5348
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