STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Msed_1424Succinate semialdehyde reductase (NADPH); Catalyzes the reduction of succinate semialdehyde to succinyl-CoA. The enzyme is specific for succinate semialdehyde and succinyl-CoA, and only shows low activity with palmitoyl-CoA. There is no activity with NAD(+) as cosubstrate. Participates in the 3- hydroxypropanoate/4-hydroxybutyrate cycle, an autotrophic CO(2) fixation pathway found in some thermoacidophilic archaea. (360 aa)    
Predicted Functional Partners:
Msed_1422
4-hydroxybutyryl-CoA synthetase.
    
 0.954
Msed_1119
PFAM: aldehyde dehydrogenase.
  
 0.936
Msed_1774
PFAM: aldehyde dehydrogenase.
  
 0.936
Msed_0406
AMP-dependent synthetase and ligase; Involved in the 3-hydroxypropionate/4-hydroxybutyrate cycle which incorporates carbon dioxide into cellular carbon. Catalyzes the ligation of coenzyme A (CoA) to 4-hydroxybutyrate (4HB). It can also use butyrate, valerate, propionate, acetate and 3-hydroxybutyrate (3HB) as substrates; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 
 0.919
Msed_0394
AMP-dependent synthetase and ligase; Catalyzes the ligation of coenzyme A (CoA) to 4- hydroxybutyrate (4HB). It can also use butyrate, valerate, propionate, acetate and 3-hydroxybutyrate (3HB) as substrates.
  
 
 0.917
Msed_0709
succinyl-CoA reductase (NADPH); Catalyzes the reduction of malonyl-CoA to malonate semialdehyde, a key step in the 3-hydroxypropanoate and the 3- hydroxypropanoate/4-hydroxybutyrate cycles. Belongs to the aspartate-semialdehyde dehydrogenase family.
    
 0.915
Msed_1062
PFAM: iron-containing alcohol dehydrogenase; 3-dehydroquinate synthase.
   
 
 0.856
Msed_0464
PFAM: Alcohol dehydrogenase, zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein.
 
  
 0.703
Msed_0601
PFAM: Alcohol dehydrogenase, zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein.
 
 
 
0.671
Msed_0398
PFAM: Alcohol dehydrogenase, zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein.
 
 
 
0.652
Your Current Organism:
Metallosphaera sedula
NCBI taxonomy Id: 399549
Other names: M. sedula DSM 5348, Metallosphaera sedula DSM 5348, Metallosphaera sedula IFO 15509, Metallosphaera sedula JCM 9185, Metallosphaera sedula NBRC 15509, Metallosphaera sedula str. DSM 5348, Metallosphaera sedula strain DSM 5348
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