STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-expression
Experiments
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[Homology]
Score
Msed_1467Aconitase; TIGRFAM: aconitate hydratase 1; PFAM: aconitate hydratase domain protein. (840 aa)    
Predicted Functional Partners:
Msed_0281
TIGRFAM: 2-methylcitrate synthase/citrate synthase II; PFAM: Citrate synthase.
 
 0.998
Msed_1522
TIGRFAM: 2-methylcitrate synthase/citrate synthase II; PFAM: Citrate synthase.
 
 0.998
Msed_0703
TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: isocitrate/isopropylmalate dehydrogenase.
  
 0.997
Msed_1462
Fumarase; PFAM: fumarate lyase.
  
 0.990
Msed_0455
PFAM: Lactate/malate dehydrogenase; Belongs to the LDH/MDH superfamily.
  
 0.982
Msed_0279
2,3-dimethylmalate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.
  
 0.958
Msed_0278
2-methylcitrate dehydratase; PFAM: MmgE/PrpD family protein.
  
 
 0.944
Msed_0088
TIGRFAM: isopropylmalate/isohomocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase.
  
 0.928
Msed_0676
TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; PFAM: ferredoxin; 4Fe-4S ferredoxin, iron-sulfur binding domain protein.
  
 
 0.899
Msed_1212
PFAM: Transketolase, central region; Transketolase domain protein.
  
 0.886
Your Current Organism:
Metallosphaera sedula
NCBI taxonomy Id: 399549
Other names: M. sedula DSM 5348, Metallosphaera sedula DSM 5348, Metallosphaera sedula IFO 15509, Metallosphaera sedula JCM 9185, Metallosphaera sedula NBRC 15509, Metallosphaera sedula str. DSM 5348, Metallosphaera sedula strain DSM 5348
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