STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Msed_1791PFAM: protein of unknown function, ATP binding. (254 aa)    
Predicted Functional Partners:
Msed_1491
PFAM: metallophosphoesterase; SMART: serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase.
  
 0.958
priS
DNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...]
 
    0.903
Msed_1797
PFAM: protein kinase; SMART: serine/threonine protein kinase.
 
 
 0.897
Msed_1365
PFAM: tyrosine specific protein phosphatase; Dual specificity protein phosphatase; SMART: protein tyrosine phosphatase, catalytic region.
  
 0.896
rpl44e
LSU ribosomal protein L44E; Binds to the 23S rRNA.
 
 
 0.886
pcn-2
Proliferating cell nuclear antigen, PCNA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family.
 
 
 0.881
Msed_0822
PFAM: band 7 protein.
 
 0.877
Msed_0329
PFAM: protein kinase; SMART: serine/threonine protein kinase.
 
 
 0.875
Msed_0833
PFAM: protein kinase; SMART: tyrosine protein kinase; serine/threonine protein kinase.
   
 0.859
Msed_0863
PFAM: protein kinase; SMART: tyrosine protein kinase; serine/threonine protein kinase.
   
 0.859
Your Current Organism:
Metallosphaera sedula
NCBI taxonomy Id: 399549
Other names: M. sedula DSM 5348, Metallosphaera sedula DSM 5348, Metallosphaera sedula IFO 15509, Metallosphaera sedula JCM 9185, Metallosphaera sedula NBRC 15509, Metallosphaera sedula str. DSM 5348, Metallosphaera sedula strain DSM 5348
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.