node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Msed_1877 | Msed_1942 | Msed_1877 | Msed_1942 | TIGRFAM: chorismate mutase; PFAM: Chorismate mutase; Prephenate dehydrogenase; NADP oxidoreductase, coenzyme F420-dependent; Shikimate/quinate 5-dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase, NAD-binding. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II. | 0.986 |
Msed_1877 | Msed_1944 | Msed_1877 | Msed_1944 | TIGRFAM: chorismate mutase; PFAM: Chorismate mutase; Prephenate dehydrogenase; NADP oxidoreductase, coenzyme F420-dependent; Shikimate/quinate 5-dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase, NAD-binding. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: histidine biosynthesis protein; Belongs to the HisA/HisF family. | 0.800 |
Msed_1877 | Msed_2182 | Msed_1877 | Msed_2182 | TIGRFAM: chorismate mutase; PFAM: Chorismate mutase; Prephenate dehydrogenase; NADP oxidoreductase, coenzyme F420-dependent; Shikimate/quinate 5-dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase, NAD-binding. | L-threonine O-3-phosphate decarboxylase; PFAM: aminotransferase, class I and II. | 0.865 |
Msed_1877 | hisB | Msed_1877 | Msed_1945 | TIGRFAM: chorismate mutase; PFAM: Chorismate mutase; Prephenate dehydrogenase; NADP oxidoreductase, coenzyme F420-dependent; Shikimate/quinate 5-dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase, NAD-binding. | PFAM: imidazoleglycerol-phosphate dehydratase. | 0.809 |
Msed_1877 | hisD | Msed_1877 | Msed_1947 | TIGRFAM: chorismate mutase; PFAM: Chorismate mutase; Prephenate dehydrogenase; NADP oxidoreductase, coenzyme F420-dependent; Shikimate/quinate 5-dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase, NAD-binding. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.771 |
Msed_1877 | hisF | Msed_1877 | Msed_1946 | TIGRFAM: chorismate mutase; PFAM: Chorismate mutase; Prephenate dehydrogenase; NADP oxidoreductase, coenzyme F420-dependent; Shikimate/quinate 5-dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase, NAD-binding. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.738 |
Msed_1877 | hisG | Msed_1877 | Msed_1943 | TIGRFAM: chorismate mutase; PFAM: Chorismate mutase; Prephenate dehydrogenase; NADP oxidoreductase, coenzyme F420-dependent; Shikimate/quinate 5-dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase, NAD-binding. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.950 |
Msed_1942 | Msed_1877 | Msed_1942 | Msed_1877 | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II. | TIGRFAM: chorismate mutase; PFAM: Chorismate mutase; Prephenate dehydrogenase; NADP oxidoreductase, coenzyme F420-dependent; Shikimate/quinate 5-dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase, NAD-binding. | 0.986 |
Msed_1942 | Msed_1944 | Msed_1942 | Msed_1944 | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: histidine biosynthesis protein; Belongs to the HisA/HisF family. | 0.981 |
Msed_1942 | Msed_1949 | Msed_1942 | Msed_1949 | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II. | TIGRFAM: imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; PFAM: glutamine amidotransferase class-I. | 0.984 |
Msed_1942 | Msed_2182 | Msed_1942 | Msed_2182 | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II. | L-threonine O-3-phosphate decarboxylase; PFAM: aminotransferase, class I and II. | 0.490 |
Msed_1942 | hisB | Msed_1942 | Msed_1945 | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II. | PFAM: imidazoleglycerol-phosphate dehydratase. | 0.999 |
Msed_1942 | hisD | Msed_1942 | Msed_1947 | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.997 |
Msed_1942 | hisE | Msed_1942 | Msed_1948 | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II. | PFAM: phosphoribosyl-ATP pyrophosphohydrolase. | 0.968 |
Msed_1942 | hisF | Msed_1942 | Msed_1946 | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.983 |
Msed_1942 | hisG | Msed_1942 | Msed_1943 | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.981 |
Msed_1942 | hisI | Msed_1942 | Msed_1950 | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.978 |
Msed_1944 | Msed_1877 | Msed_1944 | Msed_1877 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: histidine biosynthesis protein; Belongs to the HisA/HisF family. | TIGRFAM: chorismate mutase; PFAM: Chorismate mutase; Prephenate dehydrogenase; NADP oxidoreductase, coenzyme F420-dependent; Shikimate/quinate 5-dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase, NAD-binding. | 0.800 |
Msed_1944 | Msed_1942 | Msed_1944 | Msed_1942 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: histidine biosynthesis protein; Belongs to the HisA/HisF family. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II. | 0.981 |
Msed_1944 | Msed_1949 | Msed_1944 | Msed_1949 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: histidine biosynthesis protein; Belongs to the HisA/HisF family. | TIGRFAM: imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; PFAM: glutamine amidotransferase class-I. | 0.999 |