STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
Msed_2001Short chain enoyl-CoA hydratase; Plays a role in autotrophic carbon fixation via the 3- hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the reversible dehydration of 3-hydroxypropionyl-CoA to form acryloyl-CoA, and the reversible dehydration of (S)-3-hydroxybutyryl-CoA to form crotonyl- CoA. Inactive towards (R)-3-hydroxybutyryl-CoA. Belongs to the enoyl-CoA hydratase/isomerase family. (259 aa)    
Predicted Functional Partners:
Msed_0384
PFAM: Enoyl-CoA hydratase/isomerase; Belongs to the enoyl-CoA hydratase/isomerase family.
 
0.961
Msed_1456
3-hydroxypropionyl-CoA synthetase; Plays a role in the autotrophic CO(2) fixation pathway. Activates 3-hydroxypropionate to its CoA ester. Can also activate propionate, and to a lesser extent acrylate, acetate and butyrate.
  
 
 0.936
Msed_0389
PFAM: 3-hydroxyacyl-CoA dehydrogenase domain protein; 3-hydroxyacyl-CoA dehydrogenase, NAD-binding.
 
     0.913
Msed_1423
PFAM: 3-hydroxyacyl-CoA dehydrogenase domain protein; 3-hydroxyacyl-CoA dehydrogenase, NAD-binding.
 
     0.913
Msed_1426
acrylyl-CoA reductase (NADPH); Plays a role in autotrophic carbon fixation via the 3- hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the acryloyl-CoA dependent NADPH oxidation and formation of propionyl-CoA. Belongs to the zinc-containing alcohol dehydrogenase family.
   
 
 0.909
Msed_1993
3-hydroxypropionate dehydrogenase (NADP(+)); PFAM: 3-hydroxyacyl-CoA dehydrogenase domain protein; 3-hydroxyacyl-CoA dehydrogenase, NAD-binding.
 
      0.899
Msed_0656
TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase.
  
 0.851
Msed_0270
Acetyl-CoA acetyltransferase-like protein.
  
 0.850
Msed_0271
Acetyl-CoA acetyltransferase-like protein.
  
 0.849
Msed_0386
Propanoyl-CoA C-acyltransferase; PFAM: Thiolase.
  
 0.849
Your Current Organism:
Metallosphaera sedula
NCBI taxonomy Id: 399549
Other names: M. sedula DSM 5348, Metallosphaera sedula DSM 5348, Metallosphaera sedula IFO 15509, Metallosphaera sedula JCM 9185, Metallosphaera sedula NBRC 15509, Metallosphaera sedula str. DSM 5348, Metallosphaera sedula strain DSM 5348
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