STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Msed_2008PFAM: UspA domain protein. (141 aa)    
Predicted Functional Partners:
Msed_2009
Pyridine nucleotide-disulfide oxidoreductase dimerization region; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
  
  
 0.710
Msed_2006
PFAM: peptidase U62, modulator of DNA gyrase.
     
 0.636
Msed_0532
Putative signal-transduction protein with CBS domains; TIGRFAM: ribosomal subunit interface protein; PFAM: CBS domain containing protein.
  
    0.628
ogt
methylated-DNA--protein-cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
  
    0.621
Msed_2007
PFAM: peptidase U62, modulator of DNA gyrase.
     
 0.606
Msed_2005
Transcriptional regulator, CopG family; PFAM: CopG domain protein DNA-binding domain protein.
  
    0.466
Msed_2003
PFAM: homoserine dehydrogenase; homoserine dehydrogenase, NAD-binding.
     
 0.460
Msed_2004
Phosphoenolpyruvate synthase; PFAM: B3/4 domain protein.
       0.457
prf1
Peptide chain release factor subunit 1 (aeRF-1); Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
  
    0.436
Msed_0468
Putative signal-transduction protein with CBS domains; PFAM: CBS domain containing protein; 4Fe-4S ferredoxin, iron-sulfur binding domain protein.
  
    0.415
Your Current Organism:
Metallosphaera sedula
NCBI taxonomy Id: 399549
Other names: M. sedula DSM 5348, Metallosphaera sedula DSM 5348, Metallosphaera sedula IFO 15509, Metallosphaera sedula JCM 9185, Metallosphaera sedula NBRC 15509, Metallosphaera sedula str. DSM 5348, Metallosphaera sedula strain DSM 5348
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