Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Msed_2227PFAM: aldo/keto reductase. (322 aa)    
Predicted Functional Partners:
rpl37e
LSU ribosomal protein L37E; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family.
  
 
 0.871
Msed_0058
16S rRNA m(2)G 1207 methyltransferase; PFAM: methyltransferase small.
    
 0.841
Msed_0415
PFAM: NADH:flavin oxidoreductase/NADH oxidase.
  
  
 0.785
Msed_0452
PFAM: aldo/keto reductase.
 
 
0.764
fni
Isopentenyl-diphosphate delta-isomerase, type 2; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
  
 
 0.720
Msed_0533
PFAM: histone deacetylase superfamily.
   
   0.706
Msed_1556
PFAM: histone deacetylase superfamily.
   
   0.706
Msed_2228
Hypothetical protein.
       0.685
Msed_0153
TIGRFAM: glutaredoxin-like domain protein.
 
 
 0.572
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
  
 
 0.556
Your Current Organism:
Metallosphaera sedula
NCBI taxonomy Id: 399549
Other names: M. sedula DSM 5348, Metallosphaera sedula DSM 5348, Metallosphaera sedula IFO 15509, Metallosphaera sedula JCM 9185, Metallosphaera sedula NBRC 15509, Metallosphaera sedula str. DSM 5348, Metallosphaera sedula strain DSM 5348
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.