STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
Msed_2231tRNA (adenine-57, 58-N(1)-) methyltransferase; PFAM: protein-L-isoaspartate(D-aspartate) O-methyltransferase; Methyltransferase type 11. (253 aa)    
Predicted Functional Partners:
Msed_2229
Hypothetical protein.
       0.937
Msed_2230
Hypothetical protein.
       0.937
rtcA
RNA-3'-phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
   
    0.816
Msed_1938
PFAM: PP-loop domain protein.
 
  
 0.765
rpl30
PFAM: ribosomal protein L30.
   
   0.752
Msed_1487
PFAM: PP-loop domain protein.
 
  
 0.740
tmcA
Protein of unknown function DUF699, ATPase putative; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
  
  
 0.719
tmcA-2
Protein of unknown function DUF699, ATPase putative; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
  
  
 0.719
rps8e
TIGRFAM: ribosomal protein S8e; PFAM: ribosomal protein S8E.
  
    0.701
Msed_1732
Hypothetical protein.
   
  
 0.699
Your Current Organism:
Metallosphaera sedula
NCBI taxonomy Id: 399549
Other names: M. sedula DSM 5348, Metallosphaera sedula DSM 5348, Metallosphaera sedula IFO 15509, Metallosphaera sedula JCM 9185, Metallosphaera sedula NBRC 15509, Metallosphaera sedula str. DSM 5348, Metallosphaera sedula strain DSM 5348
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