Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Msed_2237TIGRFAM: AAA family ATPase, CDC48 subfamily; PFAM: AAA ATPase VAT domain protein; AAA ATPase, central domain protein; cell division protein 48, CDC48, domain 2; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase. (760 aa)    
Predicted Functional Partners:
apgM
Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate.
       0.942
Msed_0210
TIGRFAM: AAA family ATPase, CDC48 subfamily; PFAM: AAA ATPase VAT domain protein; AAA ATPase, central domain protein; cell division protein 48, CDC48, domain 2; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase.
  
  
 
0.902
Msed_0533
PFAM: histone deacetylase superfamily.
   
 0.826
Msed_1556
PFAM: histone deacetylase superfamily.
   
 0.826
rpl40e
PFAM: ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family.
  
 0.762
Msed_0813
PFAM: TPR repeat-containing protein; SMART: Tetratricopeptide domain protein.
  
 0.729
Msed_1532
PFAM: TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide domain protein.
  
 0.729
psmA
Proteasome endopeptidase complex; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
  
 0.724
Msed_0329
PFAM: protein kinase; SMART: serine/threonine protein kinase.
 
 
 0.721
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
    
 
 0.698
Your Current Organism:
Metallosphaera sedula
NCBI taxonomy Id: 399549
Other names: M. sedula DSM 5348, Metallosphaera sedula DSM 5348, Metallosphaera sedula IFO 15509, Metallosphaera sedula JCM 9185, Metallosphaera sedula NBRC 15509, Metallosphaera sedula str. DSM 5348, Metallosphaera sedula strain DSM 5348
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