STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
spt4DNA-directed RNA polymerase, subunit E'; Stimulates transcription elongation; Belongs to the archaeal Spt4 family. (65 aa)    
Predicted Functional Partners:
Msed_2241
TIGRFAM: DNA-directed RNA polymerase; PFAM: RNA binding S1 domain protein; RNA polymerase Rpb7-like.
  
 
 0.997
spt5
LSU ribosomal protein L24A; Stimulates transcription elongation; Belongs to the archaeal Spt5 family.
   
 
 0.961
Msed_2211
DNA-directed RNA polymerase, subunit P; SMART: RNA polymerase Rbp10.
   
   0.955
Msed_2239
Protein of unknown function DUF359; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).
  
    0.933
rps6e
PFAM: ribosomal protein S6e; Belongs to the eukaryotic ribosomal protein eS6 family.
  
    0.915
rps27ae
PFAM: ribosomal protein S27a; Belongs to the eukaryotic ribosomal protein eS31 family.
  
    0.914
Msed_2243
Translation initiation factor 2 subunit gamma (aeIF-2g); PFAM: protein synthesis factor, GTP-binding.
  
    0.906
Msed_2242
SSU processome protein Utp24; PFAM: PilT protein domain protein; SMART: Nucleotide binding protein, PINc.
       0.895
Msed_0033
DNA-directed RNA polymerase, subunit B' / DNA-directed RNA polymerase, subunit B; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 
 0.880
rpoH
DNA-directed RNA polymerase, subunit H; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family.
   
 
 0.874
Your Current Organism:
Metallosphaera sedula
NCBI taxonomy Id: 399549
Other names: M. sedula DSM 5348, Metallosphaera sedula DSM 5348, Metallosphaera sedula IFO 15509, Metallosphaera sedula JCM 9185, Metallosphaera sedula NBRC 15509, Metallosphaera sedula str. DSM 5348, Metallosphaera sedula strain DSM 5348
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