STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
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[Homology]
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panProteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] (379 aa)    
Predicted Functional Partners:
Msed_2114
Hypothetical protein.
  
 0.980
psmA
Proteasome endopeptidase complex; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
  
 0.940
Msed_2274
PFAM: PUA domain containing protein.
       0.938
Msed_2273
PFAM: protein of unknown function DUF75.
     
 0.935
rpl40e
PFAM: ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family.
   
 0.932
psmB1
Proteasome endopeptidase complex, beta component, Threonine peptidase, MEROPS family T01A; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
  
 0.927
psmB2
Proteasome endopeptidase complex, beta component, Threonine peptidase, MEROPS family T01A; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
  
 0.927
Msed_2276
Transcriptional regulator, XRE family; PFAM: helix-turn-helix domain protein.
  
   0.871
Msed_2277
TIGRFAM: small GTP-binding protein; PFAM: GTP-binding protein, HSR1-related; Miro domain protein.
  
    0.795
Msed_2278
Protein of unknown function DUF127; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family.
       0.788
Your Current Organism:
Metallosphaera sedula
NCBI taxonomy Id: 399549
Other names: M. sedula DSM 5348, Metallosphaera sedula DSM 5348, Metallosphaera sedula IFO 15509, Metallosphaera sedula JCM 9185, Metallosphaera sedula NBRC 15509, Metallosphaera sedula str. DSM 5348, Metallosphaera sedula strain DSM 5348
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.