STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Smar_0840Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (193 aa)    
Predicted Functional Partners:
Smar_0839
PFAM: protein of unknown function RIO1; KEGG: sto:ST0364 Mn2+-dependent serine/threonine protein kinase.
 
   
 0.947
kae1
Putative metalloendopeptidase, glycoprotease family; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37; Belongs to the KAE1 / TsaD family.
 
   
 0.945
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
  
 0.942
rps15
PFAM: ribosomal protein S15; Ribosomal S13S15-like; KEGG: ape:APE1139 30S ribosomal protein S15.
 
     0.886
rps24e
PFAM: Ribosomal protein S24e; KEGG: ape:APE1132 30S ribosomal protein S24e; Belongs to the eukaryotic ribosomal protein eS24 family.
  
    0.857
rps27ae
PFAM: Ribosomal protein S27a; KEGG: ape:APE1132a S ribosomal protein S27AE; Belongs to the eukaryotic ribosomal protein eS31 family.
       0.840
Smar_0463
TIGRFAM: phosphodiesterase, MJ0936 family; PFAM: metallophosphoesterase; KEGG: ape:APE0682 hypothetical protein.
 
  
 0.775
spt4
DNA-directed RNA polymerase, subunit E'; Stimulates transcription elongation; Belongs to the archaeal Spt4 family.
       0.757
Smar_0158
TIGRFAM: phosphodiesterase, MJ0936 family; PFAM: metallophosphoesterase; KEGG: afu:AF0799 hypothetical protein.
  
  
 0.739
rrp41
Ribosomal RNA-processing protein RRP41/SKI6; Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
  
    0.723
Your Current Organism:
Staphylothermus marinus
NCBI taxonomy Id: 399550
Other names: S. marinus F1, Staphylothermus marinus ATCC 43588, Staphylothermus marinus DSM 3639, Staphylothermus marinus F1, Staphylothermus marinus JCM 9404, Staphylothermus marinus str. F1, Staphylothermus marinus strain F1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.