STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Smar_1557PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: gka:GK2364 ABC transporter (ATP-binding protein). (224 aa)    
Predicted Functional Partners:
Smar_0113
KEGG: sai:Saci_1784 hypothetical protein.
  
 
 0.797
rpl14
LSU ribosomal protein L14P; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family.
 
     0.625
rps5
SSU ribosomal protein S5P; With S4 and S12 plays an important role in translational accuracy.
  
    0.468
rpl2
LSU ribosomal protein L2P; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family.
  
 
   0.467
Smar_1175
PFAM: H+-transporting two-sector ATPase, C subunit; KEGG: pho:PH1980 putative H+-transporting ATP synthase subunit K.
   
 
 0.462
pan
Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...]
 
     0.461
Smar_0412
TIGRFAM: MATE efflux family protein; PFAM: multi antimicrobial extrusion protein MatE; KEGG: ape:APE1773 hypothetical protein.
  
  
 0.455
Smar_0778
PFAM: ribosomal RNA adenine methylase transferase; KEGG: rbe:RBE_0204 dimethyladenosine transferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
 
  
 0.455
Smar_1441
TIGRFAM: MATE efflux family protein; PFAM: multi antimicrobial extrusion protein MatE; KEGG: pfu:PF0823 hypothetical protein.
  
  
 0.455
rpl5
LSU ribosomal protein L5P; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
 
     0.447
Your Current Organism:
Staphylothermus marinus
NCBI taxonomy Id: 399550
Other names: S. marinus F1, Staphylothermus marinus ATCC 43588, Staphylothermus marinus DSM 3639, Staphylothermus marinus F1, Staphylothermus marinus JCM 9404, Staphylothermus marinus str. F1, Staphylothermus marinus strain F1
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