Hypma_001836 protein (Hypsizygus marmoreus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

Coexpression

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[Homology]

Score

Hypma_001836

Uncharacterized protein. (511 aa)

Predicted Functional Partners:

Hypma_007510

0.651

Hypma_002824

0.450

sconC

0.450

EAF3

0.447

FRAS1

0.443

PC6

0.443

RPN11

0.442

Hypma_015741

0.441

Hypma_004754

0.430

rad9

0.430

Your Current Organism:

Hypsizygus marmoreus

NCBI taxonomy Id: 39966
Other names: H. marmoreus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EAF3	Hypma_001836	A0A369JLY1	A0A369J5Y7	Chromatin modification-related protein EAF3.	Uncharacterized protein.	0.447
FRAS1	Hypma_001836	A0A369JIX8	A0A369J5Y7	Extracellular matrix protein FRAS1.	Uncharacterized protein.	0.443
FRAS1	PC6	A0A369JIX8	A0A369K9N6	Extracellular matrix protein FRAS1.	Proprotein convertase subtilisin/kexin type 5.	0.773
Hypma_001836	EAF3	A0A369J5Y7	A0A369JLY1	Uncharacterized protein.	Chromatin modification-related protein EAF3.	0.447
Hypma_001836	FRAS1	A0A369J5Y7	A0A369JIX8	Uncharacterized protein.	Extracellular matrix protein FRAS1.	0.443
Hypma_001836	Hypma_002824	A0A369J5Y7	A0A369JA26	Uncharacterized protein.	Uncharacterized protein.	0.450
Hypma_001836	Hypma_004754	A0A369J5Y7	A0A369IZZ2	Uncharacterized protein.	Nipped-B_C domain-containing protein.	0.430
Hypma_001836	Hypma_007510	A0A369J5Y7	A0A369JVY4	Uncharacterized protein.	Protein kinase domain-containing protein.	0.651
Hypma_001836	Hypma_015741	A0A369J5Y7	A0A369KCZ2	Uncharacterized protein.	Uncharacterized protein.	0.441
Hypma_001836	PC6	A0A369J5Y7	A0A369K9N6	Uncharacterized protein.	Proprotein convertase subtilisin/kexin type 5.	0.443
Hypma_001836	RPN11	A0A369J5Y7	A0A369JT41	Uncharacterized protein.	26S proteasome non-ATPase regulatory subunit 14.	0.442
Hypma_001836	rad9	A0A369J5Y7	A0A369J3U7	Uncharacterized protein.	Sister chromatid cohesion protein.	0.430
Hypma_001836	sconC	A0A369J5Y7	A0A369JSC8	Uncharacterized protein.	E3 ubiquitin ligase complex SCF subunit sconC; Belongs to the SKP1 family.	0.450
Hypma_002824	Hypma_001836	A0A369JA26	A0A369J5Y7	Uncharacterized protein.	Uncharacterized protein.	0.450
Hypma_002824	Hypma_015741	A0A369JA26	A0A369KCZ2	Uncharacterized protein.	Uncharacterized protein.	0.903
Hypma_002824	RPN11	A0A369JA26	A0A369JT41	Uncharacterized protein.	26S proteasome non-ATPase regulatory subunit 14.	0.815
Hypma_004754	Hypma_001836	A0A369IZZ2	A0A369J5Y7	Nipped-B_C domain-containing protein.	Uncharacterized protein.	0.430
Hypma_007510	Hypma_001836	A0A369JVY4	A0A369J5Y7	Protein kinase domain-containing protein.	Uncharacterized protein.	0.651
Hypma_007510	Hypma_015741	A0A369JVY4	A0A369KCZ2	Protein kinase domain-containing protein.	Uncharacterized protein.	0.686
Hypma_015741	Hypma_001836	A0A369KCZ2	A0A369J5Y7	Uncharacterized protein.	Uncharacterized protein.	0.441

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

26

average node degree:

4.73

avg. local clustering coefficient:

0.941

expected number of edges:

20

PPI enrichment p-value:

0.123

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1903298

Negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

4 of 4

3.98

5.92

2.26e-11

GO:0071456

Cellular response to hypoxia

4 of 608

1.8

1.89

7.88e-05

GO:0033554

Cellular response to stress

5 of 3767

1.1

0.84

0.0035

GO:0070887

Cellular response to chemical stimulus

5 of 6264

0.88

0.5

0.0356

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140662

ATP-dependent protein folding chaperone

5 of 220

2.34

3.66

5.39e-08

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0034663

Endoplasmic reticulum chaperone complex

4 of 31

3.09

4.75

1.97e-09

GO:0005788

Endoplasmic reticulum lumen

5 of 140

2.53

4.48

1.97e-09

GO:0099503

Secretory vesicle

4 of 235

2.21

2.8

2.61e-06

GO:0000325

Plant-type vacuole

4 of 1274

1.48

1.3

0.00077

GO:0070013

Intracellular organelle lumen

6 of 3685

1.19

0.00014

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:95099

Riboflavin kinase domain superfamily, and FAD biosynthetic process

4 of 15

3.41

4.64

3.88e-09

CL:3745

Mixed, incl. Heat shock protein 70 family, and Heat shock protein Hsp90 family

5 of 117

2.61

4.33

5.31e-09

CL:3776

Mixed, incl. Heat shock protein 70 family, and Heat shock protein Hsp90, conserved site

3 of 34

2.93

2.73

1.02e-05

CL:3954

Mixed, incl. Regulation of intrinsic apoptotic signaling pathway, and Nucleotide exchange factor Fes1

2 of 5

3.58

2.13

0.00015

CL:95101

Riboflavin kinase domain, bacterial/eukaryotic, and FAD biosynthetic process

2 of 8

3.38

1.96

0.00030

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00740

Riboflavin metabolism

4 of 276

2.14

2.89

1.26e-06

map04141

Protein processing in endoplasmic reticulum

6 of 1598

1.55

2.18

8.52e-07

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-381070

IRE1alpha activates chaperones

5 of 37

3.11

6.23

3.22e-12

MAP-381119

Unfolded Protein Response (UPR)

5 of 91

2.72

5.22

1.16e-10

MAP-8953897

Cellular responses to stimuli

6 of 2435

1.37

1.6

1.78e-05

MAP-2262752

Cellular responses to stress

6 of 2406

1.38

1.6

1.78e-05

MAP-5653656

Vesicle-mediated transport

5 of 1735

1.44

1.52

9.24e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0034663

Endoplasmic reticulum chaperone complex

5 of 41

3.07

5.96

9.86e-12

GOCC:0110165

Cellular anatomical entity

7 of 8339

0.9

0.7

0.0027

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13419

Haloacid dehalogenase-like hydrolase

3 of 49

2.77

2.3

6.15e-05

PF06723

MreB/Mbl protein

3 of 95

2.48

1.97

0.00021

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR023198

Phosphoglycolate phosphatase-like, domain 2

4 of 39

2.99

3.88

7.55e-08

IPR023465

Riboflavin kinase domain superfamily

3 of 6

3.68

3.6

3.38e-07

IPR041492

Haloacid dehalogenase-like hydrolase

4 of 76

2.7

3.47

3.38e-07

IPR006439

HAD hydrolase, subfamily IA

4 of 73

2.72

3.47

3.38e-07

IPR018181

Heat shock protein 70, conserved site

4 of 92

2.62

3.4

4.05e-07

(more ...)

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