node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FUMR | Hypma_012793 | A0A369K427 | A0A369JMM1 | Fumarate hydratase, mitochondrial. | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8-A, mitochondrial. | 0.770 |
FUMR | Hypma_013989 | A0A369K427 | A0A369KEC9 | Fumarate hydratase, mitochondrial. | Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer. | 0.647 |
FUMR | Hypma_015198 | A0A369K427 | A0A369K4B6 | Fumarate hydratase, mitochondrial. | Cytochrome b-c1 complex subunit Rieske, mitochondrial; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. | 0.763 |
FUMR | SCOA | A0A369K427 | A0A369K3Q2 | Fumarate hydratase, mitochondrial. | Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.959 |
FUMR | SDH2 | A0A369K427 | A0A369J9Q8 | Fumarate hydratase, mitochondrial. | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). | 0.960 |
FUMR | ifcA | A0A369K427 | A0A369J7N7 | Fumarate hydratase, mitochondrial. | Fumarate reductase flavoprotein subunit. | 0.941 |
FUMR | nuo-49 | A0A369K427 | A0A369J5N3 | Fumarate hydratase, mitochondrial. | NADH-ubiquinone oxidoreductase subunit, mitochondrial; Belongs to the complex I 49 kDa subunit family. | 0.517 |
FUMR | nuo-51 | A0A369K427 | A0A369KBL7 | Fumarate hydratase, mitochondrial. | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. | 0.869 |
FUMR | sdh3 | A0A369K427 | A0A369K2Y6 | Fumarate hydratase, mitochondrial. | Succinate dehydrogenase cytochrome B subunit, mitochondrial. | 0.943 |
FUMR | sdh4 | A0A369K427 | A0A369J5L2 | Fumarate hydratase, mitochondrial. | Succinate dehydrogenase [ubiquinone] cytochrome b small subunit. | 0.930 |
Hypma_012793 | FUMR | A0A369JMM1 | A0A369K427 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8-A, mitochondrial. | Fumarate hydratase, mitochondrial. | 0.770 |
Hypma_012793 | Hypma_015198 | A0A369JMM1 | A0A369K4B6 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8-A, mitochondrial. | Cytochrome b-c1 complex subunit Rieske, mitochondrial; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. | 0.998 |
Hypma_012793 | SCOA | A0A369JMM1 | A0A369K3Q2 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8-A, mitochondrial. | Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.912 |
Hypma_012793 | SDH2 | A0A369JMM1 | A0A369J9Q8 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8-A, mitochondrial. | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). | 0.987 |
Hypma_012793 | ifcA | A0A369JMM1 | A0A369J7N7 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8-A, mitochondrial. | Fumarate reductase flavoprotein subunit. | 0.946 |
Hypma_012793 | nuo-49 | A0A369JMM1 | A0A369J5N3 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8-A, mitochondrial. | NADH-ubiquinone oxidoreductase subunit, mitochondrial; Belongs to the complex I 49 kDa subunit family. | 0.999 |
Hypma_012793 | nuo-51 | A0A369JMM1 | A0A369KBL7 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8-A, mitochondrial. | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. | 0.999 |
Hypma_012793 | sdh3 | A0A369JMM1 | A0A369K2Y6 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8-A, mitochondrial. | Succinate dehydrogenase cytochrome B subunit, mitochondrial. | 0.958 |
Hypma_012793 | sdh4 | A0A369JMM1 | A0A369J5L2 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8-A, mitochondrial. | Succinate dehydrogenase [ubiquinone] cytochrome b small subunit. | 0.949 |
Hypma_013989 | FUMR | A0A369KEC9 | A0A369K427 | Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer. | Fumarate hydratase, mitochondrial. | 0.647 |